Title
Outcomes of in-hospital cardiac arrest in COVID-19 patients: A proportional prevalence meta-analysis
UMMS Affiliation
Department of Medicine, Division of Cardiovascular Medicine
Publication Date
2021-02-04
Document Type
Article
Disciplines
Cardiology | Cardiovascular Diseases | Clinical Epidemiology | Epidemiology | Infectious Disease | Virus Diseases
Abstract
BACKGROUND: Limited epidemiological data are available on the outcomes of in-hospital cardiac arrest (CA) in COVID-19 patients.
METHODS: We performed literature search of PubMed, EMBASE, Cochrane, and Ovid to identify research articles that studied outcomes of in-hospital cardiac arrest in COVID-19 patients. The primary outcome was survival at discharge. Secondary outcomes included return of spontaneous circulation (ROSC) and types of cardiac arrest. Pooled percentages with a 95% confidence interval (CI) were calculated for the prevalence of outcomes.
RESULTS: A total of 7,891 COVID patients were included in the study. There were 621 (pooled prevalence 8%, 95% CI 4-13%) cardiac arrest patients. There were 52 (pooled prevalence 3.0%; 95% CI 0.0-10.0%) patients that survived at the time of discharge. ROSC was achieved in 202 (pooled prevalence 39%;95% CI 21.0-59.0%) patients. Mean time to ROSC was 7.74 (95% CI 7.51-7.98) min. The commonest rhythm at the time of cardiac arrest was pulseless electrical activity (pooled prevalence 46%; 95% 13-80%), followed by asystole (pooled prevalence 40%; 95% CI 6-80%). Unstable ventricular arrhythmia occurred in a minority of patients (pooled prevalence 8%; 95% CI 4-13%).
CONCLUSION: This pooled analysis of studies showed that the survival post in-hospital cardiac arrest in COVID patients is dismal despite adequate ROSC obtained at the time of resuscitation. Nonshockable rhythm cardiac arrest is commoner suggesting a non-cardiac cause while cardiac related etiology is uncommon. Future studies are needed to improve the survival in these patients.
Keywords
COVID-19, in-hospital cardiac arrest, mortality, pulseless electrical activity
DOI of Published Version
10.1002/ccd.29525
Source
Mir T, Sattar Y, Ahmad J, Ullah W, Shanah L, Alraies MC, Qureshi WT. Outcomes of in-hospital cardiac arrest in COVID-19 patients: A proportional prevalence meta-analysis. Catheter Cardiovasc Interv. 2021 Feb 4. doi: 10.1002/ccd.29525. Epub ahead of print. PMID: 33543564. Link to article on publisher's site
Journal/Book/Conference Title
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography and Interventions
Related Resources
PubMed ID
33543564
Repository Citation
Mir T, Sattar Y, Ahmad J, Ullah W, Shanah L, Alraies MC, Qureshi W. (2021). Outcomes of in-hospital cardiac arrest in COVID-19 patients: A proportional prevalence meta-analysis. COVID-19 Publications by UMMS Authors. https://doi.org/10.1002/ccd.29525. Retrieved from https://escholarship.umassmed.edu/covid19/179