Eye Diseases Direct Interest to Complement Pathway and Macrophages as Regulators of Inflammation in COVID-19
UMass Chan Affiliations
Department of Ophthalmology and Visual SciencesDocument Type
Journal ArticlePublication Date
2020-12-07Keywords
complementCOVID-19
inflammation
lifestyles
macrophages
macular degeneration
Eye Diseases
Immunology and Infectious Disease
Infectious Disease
Ophthalmology
Virus Diseases
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Show full item recordAbstract
Many of the risk factors for developing severe coronavirus disease 2019 (COVID-19) are also risk factors for eye diseases such as age-related macular degeneration (AMD). During the past decades, macrophages and the complement pathway (as a part of the innate immune system) have been identified as important contributors to the development of AMD, and we suggest that these mechanisms are of similar importance for the clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Based on the experience with AMD, we discuss how behavioral factors such as diet, smoking and higher body mass index, as well as genetic determinants such as the complement and immune pathway genes may lead to the overactive inflammatory phenotypes seen in some patients with COVID-19, and may in part explain the heterogeneity of disease manifestations and outcomes. Based on this experience, we discuss potential genetic research projects and elaborate on preventive and treatment approaches related to COVID-19.Source
Jager MJ, Seddon JM. Eye Diseases Direct Interest to Complement Pathway and Macrophages as Regulators of Inflammation in COVID-19. Asia Pac J Ophthalmol (Phila). 2020 Dec 7;10(1):114-120. doi: 10.1097/APO.0000000000000346. PMID: 33290288. Link to article on publisher's site
DOI
10.1097/APO.0000000000000346Permanent Link to this Item
http://hdl.handle.net/20.500.14038/27360PubMed ID
33290288Related Resources
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Copyright 2020 Asia-Pacific Academy of Ophthalmology. Published by Wolters Kluwer Health, Inc. on behalf of the Asia-Pacific Academy of Ophthalmology. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBYNC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1097/APO.0000000000000346
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Except where otherwise noted, this item's license is described as Copyright 2020 Asia-Pacific Academy of Ophthalmology. Published by Wolters Kluwer Health, Inc. on behalf of the Asia-Pacific Academy of Ophthalmology. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBYNC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
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