Title

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

UMMS Affiliation

Department of Neurology

Publication Date

2020-11-07

Document Type

Article

Disciplines

Immunology of Infectious Disease | Immunopathology | Infectious Disease | Nervous System | Nervous System Diseases | Neuroscience and Neurobiology | Virus Diseases

Abstract

Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates that besides common COVID-19 symptoms, patients may develop various neurological manifestations affecting both the central and peripheral nervous systems as well as skeletal muscles. These manifestations can occur prior, during and even after the onset of COVID-19 general symptoms. In this Review, we discuss the possible neuroimmunological mechanisms underlying the nervous system and skeletal muscle involvement, and viral triggered neuroimmunological conditions associated with SARS-CoV-2, as well as therapeutic approaches that have been considered for these specific complications worldwide.

Keywords

Coronavirus disease 2019 (COVID-19), Encephalitis, Guillain-Barré syndromes, Myelitis, Neuroimmunity, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

DOI of Published Version

10.1016/j.jneuroim.2020.577436

Source

Keyhanian K, Umeton RP, Mohit B, Davoudi V, Hajighasemi F, Ghasemi M. SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation. J Neuroimmunol. 2020 Nov 7;350:577436. doi: 10.1016/j.jneuroim.2020.577436. Epub ahead of print. PMID: 33212316; PMCID: PMC7647896. Link to article on publisher's site

Journal/Book/Conference Title

Journal of neuroimmunology

Related Resources

Link to Article in PubMed

PubMed ID

33212316

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