Title
SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation
UMMS Affiliation
Department of Neurology
Publication Date
2020-11-07
Document Type
Article
Disciplines
Immunology of Infectious Disease | Immunopathology | Infectious Disease | Nervous System | Nervous System Diseases | Neuroscience and Neurobiology | Virus Diseases
Abstract
Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates that besides common COVID-19 symptoms, patients may develop various neurological manifestations affecting both the central and peripheral nervous systems as well as skeletal muscles. These manifestations can occur prior, during and even after the onset of COVID-19 general symptoms. In this Review, we discuss the possible neuroimmunological mechanisms underlying the nervous system and skeletal muscle involvement, and viral triggered neuroimmunological conditions associated with SARS-CoV-2, as well as therapeutic approaches that have been considered for these specific complications worldwide.
Keywords
Coronavirus disease 2019 (COVID-19), Encephalitis, Guillain-Barré syndromes, Myelitis, Neuroimmunity, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
DOI of Published Version
10.1016/j.jneuroim.2020.577436
Source
Keyhanian K, Umeton RP, Mohit B, Davoudi V, Hajighasemi F, Ghasemi M. SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation. J Neuroimmunol. 2020 Nov 7;350:577436. doi: 10.1016/j.jneuroim.2020.577436. Epub ahead of print. PMID: 33212316; PMCID: PMC7647896. Link to article on publisher's site
Journal/Book/Conference Title
Journal of neuroimmunology
Related Resources
PubMed ID
33212316
Repository Citation
Keyhanian K, Umeton RP, Mohit B, Davoudi V, Hajighasemi F, Ghasemi M. (2020). SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation. COVID-19 Publications by UMMS Authors. https://doi.org/10.1016/j.jneuroim.2020.577436. Retrieved from https://escholarship.umassmed.edu/covid19/150