Title

ACEing COVID-19: A Role For Angiotensin Axis Inhibition in SARS-CoV-2 infection

UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine

Publication Date

2020-04-17

Document Type

Article

Disciplines

Cardiology | Cardiovascular Diseases | Immunology and Infectious Disease | Infectious Disease | Virus Diseases

Abstract

Cardiometabolic disease, especially hypertension, is a common risk factor for mortality among individuals with SARS-CoV-2 disease (COVID-19). The role of hypertension and vascular disease in COVID-19 has raised considerable debate around how to best manage anti-hypertensive therapy to alter disease trajectory. Given the role of the ACE2 receptor in SARS-CoV-2 viral entry6, angiotensin system modulation by ACE inhibitors (ACE-I) or angiotensin-II receptor blockers (ARBs) in clinical management have taken center stage in this controversy.

Keywords

Infection, hypertension, COVID-19

DOI of Published Version

10.1161/CIRCRESAHA.120.317174

Source

Shah R, Murthy VL, Koupenova M. ACEing COVID-19: A Role For Angiotensin Axis Inhibition in SARS-CoV-2 infection? Circ Res. 2020 Apr 17. doi: 10.1161/CIRCRESAHA.120.317174. Epub ahead of print. PMID: 32302248. Link to article on publisher's site

Journal/Book/Conference Title

Circulation research

Related Resources

Link to Article in PubMed

PubMed ID

32302248

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