UMMS Affiliation
Department of Medicine, Division of Cardiovascular Medicine
Publication Date
2020-08-26
Document Type
Article
Disciplines
Amino Acids, Peptides, and Proteins | Cell Biology | Cells | Cellular and Molecular Physiology | Immunology and Infectious Disease | Infectious Disease | Nucleic Acids, Nucleotides, and Nucleosides | Physiological Processes | Virus Diseases
Abstract
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. Of the extracellular vesicles, exosomes are the most widely sorted and extensively explored for their contents and function. The size of the nanovesicular structures (exosomes) range from 30 to 140 nm and are present in various biological fluids such as saliva, plasma, urine etc. These cargo-laden extracellular vesicles arise from endosome-derived multivesicular bodies and are known to carry proteins and nucleic acids. Exosomes are involved in multiple physiological and pathological processes, including cellular senescence. Exosomes mediate signaling crosstalk and play a critical role in cell-cell communications. Exosomes have evolved as potential biomarkers for aging-related diseases. Aging, a physiological process, involves a progressive decline of function of organs with a loss of homeostasis and increasing probability of illness and death. The review focuses on the classic view of exosome biogenesis, biology, and age-associated changes. Owing to their ability to transport biological information among cells, the review also discusses the interplay of senescent cell-derived exosomes with the aging process, including the susceptibility of the aging population to COVID-19 infections.
Keywords
COVID-19, aging, exosomes, extracellular vesicles, miRNA
Rights and Permissions
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DOI of Published Version
10.3390/cells9091974
Source
Saheera S, Potnuri AG, Krishnamurthy P. Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies. Cells. 2020 Aug 26;9(9):E1974. doi: 10.3390/cells9091974. PMID: 32859053. View article on publisher's website
Journal/Book/Conference Title
Cells
Related Resources
PubMed ID
32859053
Repository Citation
Saheera S, Potnuri A, Krishnamurthy P. (2020). Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies. COVID-19 Publications by UMMS Authors. https://doi.org/10.3390/cells9091974. Retrieved from https://escholarship.umassmed.edu/covid19/108
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Amino Acids, Peptides, and Proteins Commons, Cell Biology Commons, Cells Commons, Cellular and Molecular Physiology Commons, Immunology and Infectious Disease Commons, Infectious Disease Commons, Nucleic Acids, Nucleotides, and Nucleosides Commons, Physiological Processes Commons, Virus Diseases Commons