Acute kidney injury and cardiovascular outcomes in acute severe hypertension
Authors
Szczech, Lynda A.Granger, Christopher B.
Dasta, Joseph F.
Amin, Alpesh
Peacock, W. Frank
McCullough, Peter A.
Devlin, John W.
Weir, Matthew R.
Katz, Jason N.
Anderson, Frederick A. Jr.
Wyman, Allison
Varon, Joseph
UMass Chan Affiliations
Center for Outcomes ResearchDocument Type
Journal ArticlePublication Date
2010-05-12Keywords
Acute DiseaseAdult
Aged
Antihypertensive Agents
Cardiovascular System
Chronic Disease
Cohort Studies
Comorbidity
Female
Glomerular Filtration Rate
Hospitalization
Humans
Hypertension
Kidney Diseases
Male
Middle Aged
Morbidity
Risk Assessment
Severity of Illness Index
Cardiovascular Diseases
Health Services Research
Metadata
Show full item recordAbstract
BACKGROUND: Little is known about the association of kidney dysfunction and outcome in acute severe hypertension. This study aimed to measure the association between baseline chronic kidney disease (estimated glomerular filtration rate), acute kidney injury (AKI, decrease in estimated glomerular filtration rate > or =25% from baseline) and outcome in patients hospitalized with acute severe hypertension. METHODS AND RESULTS: The Studying the Treatment of Acute Hypertension (STAT) registry enrolled patients with acute severe hypertension, defined as > or =1 blood pressure measurement >180 mm Hg systolic and/or >110 mm Hg diastolic and treated with intravenous antihypertensive therapy. Data were compared across groups categorized by admission estimated glomerular filtration rate and AKI during admission. On admission, 79% of the cohort (n=1566) had at least mild chronic kidney disease (estimated glomerular filtration rate/min in 46%,/min in 22%). Chronic kidney disease patients were more likely to develop heart failure (P CONCLUSIONS: Chronic kidney disease is a common comorbidity among patients admitted with acute severe hypertension, and AKI is a frequent form of acute target organ dysfunction, particularly in those with baseline chronic kidney disease. Any degree of AKI is associated with a greater risk of morbidity and mortality.Source
Circulation. 2010 May 25;121(20):2183-91. Epub 2010 May 10. Link to article on publisher's siteDOI
10.1161/CIRCULATIONAHA.109.896597Permanent Link to this Item
http://hdl.handle.net/20.500.14038/27311PubMed ID
20458014Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1161/CIRCULATIONAHA.109.896597