Title
Stenting and glycoprotein IIb/IIIa inhibition in patients with acute myocardial infarction undergoing percutaneous coronary intervention: findings from the global registry of acute coronary events (GRACE)
UMMS Affiliation
Center for Outcomes Research; Department of Medicine, Division of Cardiovascular Medicine
Publication Date
2003-10-23
Document Type
Article
Subjects
Adult; Aged; Americas; *Angioplasty, Balloon, Coronary; Australia; Blood Vessel Prosthesis Implantation; Combined Modality Therapy; Coronary Artery Bypass; Coronary Disease; Europe; Female; Fibrinolytic Agents; Hospital Mortality; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; New Zealand; Platelet Glycoprotein GPIIb-IIIa Complex; inhibitors; Postoperative Complications; Registries; Risk Factors; *Stents; Time Factors; Treatment Outcome
Disciplines
Health Services Research
Abstract
Stenting and GP IIb/IIIa inhibition are promising adjunctive therapies in PCI. The Global Registry of Acute Coronary Events (GRACE) is a registry of unselected patients with acute coronary syndromes, allowing for the study of treatments in a real-world environment. Data from GRACE patients with AMI who underwent PCI were analyzed. After adjusting for demographics, baseline characteristics, and previous medications, treatment with GP IIb/IIIa inhibitors and a stent and treatment with a stent alone were significant predictors of survival at 6 months. Stents were used in 90.9% of patients. GP IIb/IIIa inhibitors were used in 59.7%; in most cases they were started after the beginning of the procedure. The in-hospital death rate (7.6%) was highest in patients undergoing urgent PCI. Mortality at 6 months following PCI was 14.4% among patients who received neither GP IIb/IIIa inhibitors nor a stent, compared to patients who received both GP IIb/IIIa inhibitors and a stent (7.3%), GP IIb/IIIa inhibitors alone (12.8%), or a stent alone (6.7%).
DOI of Published Version
10.1002/ccd.10653
Source
Catheter Cardiovasc Interv. 2003 Nov;60(3):360-7. Link to article on publisher's site
Journal/Book/Conference Title
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography and Interventions
Related Resources
PubMed ID
14571488
Repository Citation
Montalescot, Gilles; Van de Werf, Frans; Gulba, Dietrich C.; Avezum, Alvaro; Brieger, David; Kennelly, Brian M.; Mazurek, Tomasz; Spencer, Frederick A.; White, Kami; and Gore, Joel M., "Stenting and glycoprotein IIb/IIIa inhibition in patients with acute myocardial infarction undergoing percutaneous coronary intervention: findings from the global registry of acute coronary events (GRACE)" (2003). GRACE Publications. 82.
https://escholarship.umassmed.edu/cor_grace/82