Title
Stenting and glycoprotein IIb/IIIa inhibition in patients with acute myocardial infarction undergoing percutaneous coronary intervention: findings from the global registry of acute coronary events (GRACE)
UMMS Affiliation
Center for Outcomes Research; Department of Medicine, Division of Cardiovascular Medicine
Publication Date
2003-10-23
Document Type
Article
Subjects
Adult; Aged; Americas; *Angioplasty, Balloon, Coronary; Australia; Blood Vessel Prosthesis Implantation; Combined Modality Therapy; Coronary Artery Bypass; Coronary Disease; Europe; Female; Fibrinolytic Agents; Hospital Mortality; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; New Zealand; Platelet Glycoprotein GPIIb-IIIa Complex; inhibitors; Postoperative Complications; Registries; Risk Factors; *Stents; Time Factors; Treatment Outcome
Disciplines
Health Services Research
Abstract
Stenting and GP IIb/IIIa inhibition are promising adjunctive therapies in PCI. The Global Registry of Acute Coronary Events (GRACE) is a registry of unselected patients with acute coronary syndromes, allowing for the study of treatments in a real-world environment. Data from GRACE patients with AMI who underwent PCI were analyzed. After adjusting for demographics, baseline characteristics, and previous medications, treatment with GP IIb/IIIa inhibitors and a stent and treatment with a stent alone were significant predictors of survival at 6 months. Stents were used in 90.9% of patients. GP IIb/IIIa inhibitors were used in 59.7%; in most cases they were started after the beginning of the procedure. The in-hospital death rate (7.6%) was highest in patients undergoing urgent PCI. Mortality at 6 months following PCI was 14.4% among patients who received neither GP IIb/IIIa inhibitors nor a stent, compared to patients who received both GP IIb/IIIa inhibitors and a stent (7.3%), GP IIb/IIIa inhibitors alone (12.8%), or a stent alone (6.7%).
DOI of Published Version
10.1002/ccd.10653
Source
Catheter Cardiovasc Interv. 2003 Nov;60(3):360-7. Link to article on publisher's site
Journal/Book/Conference Title
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography and Interventions
Related Resources
PubMed ID
14571488
Repository Citation
Montalescot G, Van de Werf F, Gulba DC, Avezum A, Brieger D, Kennelly BM, Mazurek T, Spencer FA, White K, Gore JM. (2003). Stenting and glycoprotein IIb/IIIa inhibition in patients with acute myocardial infarction undergoing percutaneous coronary intervention: findings from the global registry of acute coronary events (GRACE). GRACE Publications. https://doi.org/10.1002/ccd.10653. Retrieved from https://escholarship.umassmed.edu/cor_grace/82