Effectiveness of primary percutaneous coronary intervention compared with that of thrombolytic therapy in elderly patients with acute myocardial infarction
Center for Outcomes Research; Department of Medicine, Division of Cardiovascular Medicine
Aged; *Angioplasty, Balloon, Coronary; Electrocardiography; Hemorrhage; Hospital Mortality; Humans; Myocardial Infarction; Odds Ratio; Recurrence; Registries; Stents; Streptokinase; Stroke; *Thrombolytic Therapy
Health Services Research
BACKGROUND: Few data exist from a community-based perspective on the relative effectiveness of primary percutaneous coronary intervention (PCI) as compared with thrombolytic therapy (TT) in elderly patients with ST-elevation myocardial infarction (STEMI), particularly in the current era of coronary stents and newer antithrombotic agents.
METHODS: We evaluated data from patients, aged > or =70 years, with STEMI who were enrolled in the Global Registry of Acute Coronary Events study between April 1999, and September 2002.
RESULTS: Of the 2975 elderly patients eligible for reperfusion therapy, 365 (12.7%) underwent primary PCI and 769 (26.7%) received TT. The median delay from hospital arrival to therapy was 105 minutes for primary PCI and 40 minutes for TT. Inhospital complications for primary PCI versus TT included mortality (13.5% vs 14.8%), reinfarction (1.1% vs 5.7%), composite of death or reinfarction (14.3% vs 18.7%), cardiogenic shock (11.3% vs 11.6%), major bleeding (8.6% vs 5.9%), and stroke (1.1% vs 2.8%). After adjustment for baseline differences and propensity score, patients receiving primary PCI showed a lower rate of reinfarction (odds ratio [OR], 0.15; 95% CI, 0.05-0.44) and mortality (OR, 0.62; 95% CI, 0.39-0.96) and the composite of reinfarction or death (OR, 0.53; 95% CI, 0.35-0.79), with no difference in other outcome measures.
CONCLUSION: Our data suggest that, compared with TT, primary PCI is associated with a decrease in reinfarction and mortality, with no change in other outcome measures, in elderly patients with STEMI. These findings from an observational registry require further confirmation in future randomized clinical trial assessing the optimal reperfusion strategy in the elderly cohort with STEMI.
DOI of Published Version
Am Heart J. 2004 Feb;147(2):253-9. Link to article on publisher's site
American heart journal
Mehta, Rajendra H.; Sadiq, Immad; Goldberg, Robert J.; Gore, Joel M.; Avezum, Alvaro; Spencer, Frederick A.; Kline-Rogers, Eva M.; Allegrone, Jeanna; Pieper, Karen S.; Fox, Keith A. A.; Eagle, Kim A.; and GRACE Investigators, "Effectiveness of primary percutaneous coronary intervention compared with that of thrombolytic therapy in elderly patients with acute myocardial infarction" (2004). GRACE Publications. 77.