A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry
Center for Outcomes Research; Department of Medicine, Division of Cardiovascular Medicine
Aged; Angina, Unstable; Cause of Death; *Decision Support Techniques; Female; Hospitalization; Humans; Male; Middle Aged; Myocardial Ischemia; Registries; *Risk Assessment
Health Services Research
CONTEXT: Accurate estimation of risk for untoward outcomes after patients have been hospitalized for an acute coronary syndrome (ACS) may help clinicians guide the type and intensity of therapy.
OBJECTIVE: To develop a simple decision tool for bedside risk estimation of 6-month mortality in patients surviving admission for an ACS.
DESIGN, SETTING, AND PATIENTS: A multinational registry, involving 94 hospitals in 14 countries, that used data from the Global Registry of Acute Coronary Events (GRACE) to develop and validate a multivariable stepwise regression model for death during 6 months postdischarge. From 17,142 patients presenting with an ACS from April 1, 1999, to March 31, 2002, and discharged alive, 15,007 (87.5%) had complete 6-month follow-up and represented the development cohort for a model that was subsequently tested on a validation cohort of 7638 patients admitted from April 1, 2002, to December 31, 2003.
MAIN OUTCOME MEASURE: All-cause mortality during 6 months postdischarge after admission for an ACS.
RESULTS: The 6-month mortality rates were similar in the development (n = 717; 4.8%) and validation cohorts (n = 331; 4.7%). The risk-prediction tool for all forms of ACS identified 9 variables predictive of 6-month mortality: older age, history of myocardial infarction, history of heart failure, increased pulse rate at presentation, lower systolic blood pressure at presentation, elevated initial serum creatinine level, elevated initial serum cardiac biomarker levels, ST-segment depression on presenting electrocardiogram, and not having a percutaneous coronary intervention performed in hospital. The c statistics for the development and validation cohorts were 0.81 and 0.75, respectively.
CONCLUSIONS: The GRACE 6-month postdischarge prediction model is a simple, robust tool for predicting mortality in patients with ACS. Clinicians may find it simple to use and applicable to clinical practice.
DOI of Published Version
JAMA. 2004 Jun 9;291(22):2727-33. Link to article on publisher's site
JAMA : the journal of the American Medical Association
Eagle, Kim A.; Lim, Michael J.; Dabbous, Omar H.; Pieper, Karen S.; Goldberg, Robert J.; Van de Werf, Frans; Goodman, Shaun G.; Granger, Christopher B.; Steg, Phillippe Gabriel; Gore, Joel M.; Budaj, Andrzej; Avezum, Alvaro; Flather, Marcus D.; Fox, Keith A. A.; and GRACE Investigators, "A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry" (2004). GRACE Publications. 75.