ALS C.A.R.E. Publications


Use of noninvasive ventilation in patients with amyotrophic lateral sclerosis

UMMS Affiliation

Center for Outcomes Research

Publication Date


Document Type



Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Cross-Sectional Studies; Demography; Female; Humans; Intermittent Positive-Pressure Ventilation; numerical data; Male; Middle Aged; Retrospective Studies; Sex Factors; Sickness Impact Profile; Social Support; Socioeconomic Factors; Survival Analysis; Time Factors; Treatment Outcome


Health Services Research


INTRODUCTION: Noninvasive positive pressure ventilation (NIPPV) is associated with improved survival in amyotrophic lateral sclerosis (ALS) and has been widely recommended. The extent of NIPPV use in ALS patients and the factors associated with its use have not been studied.

METHODS: A cross-sectional study using the ALS Patient Care Database. Analyses were performed to assess the association of patient and care characteristics with use of ventilatory support.

RESULTS: 1458 patients were studied. 15.6% used NIPPV and 2.1% used invasive mechanical ventilation. Patients who used NIPPV were significantly more likely to be male and have higher income than those who did not. They were also more likely to have a gastrostomy tube, lower vital capacity, more severe disease, bulbar involvement and poorer general health status as measured by the SF-12 and Sickness Impact Profile. Multivariate analysis revealed that lower FVC, higher income and use of gastrostomy tube were independently associated with use of NIPPV.

CONCLUSIONS: NIPPV is used more than seven times as frequently as invasive ventilation in ALS patients. Patients who use NIPPV have more severe disease than those who do not use any respiratory intervention. Patients with lower income are less likely to use NIPPV, which raises concerns about disparities in the care of patients with ALS.

DOI of Published Version



Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Mar;5(1):9-15. Link to article on publisher's site

Journal/Book/Conference Title

Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases

Related Resources

Link to Article in PubMed

PubMed ID