Safety and cost-effectiveness of paclitaxel administered as a 1-hour infusion versus a 3-hour infusion for various malignancies
Department of Pharmacy
Adult; Aged; Aged, 80 and over; Cost-Benefit Analysis; Female; *Health Care Costs; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Paclitaxel; *Safety; Time Factors
Pharmacy and Pharmaceutical Sciences
This study challenges the current practice of administering paclitaxel for a variety of malignancies over 3 hours and documents the safety and cost-effectiveness of 1-hour administration in the outpatient setting. The authors investigated opportunities to save nursing time and costs in a cancer clinic without compromising patient safety. These savings are referred to as "opportunity-cost savings" that enable the clinic to schedule more patients during the time normally required to administer a 3-hour paclitaxel dose. Over a 2-year period, the authors were able to document significant time savings with no increase in adverse drug reactions.
J Infus Nurs. 2004 Jul-Aug;27(4):251-3.
Journal of infusion nursing : the official publication of the Infusion Nurses Society
Gammon DC, Lizotte MW. (2004). Safety and cost-effectiveness of paclitaxel administered as a 1-hour infusion versus a 3-hour infusion for various malignancies. Clinical Pharmacy Services Publications. Retrieved from https://escholarship.umassmed.edu/clinpharm_pp/5