Clinical Pharmacy Services Publications


Safety and cost-effectiveness of paclitaxel administered as a 1-hour infusion versus a 3-hour infusion for various malignancies

UMMS Affiliation

Department of Pharmacy



Document Type


Medical Subject Headings

Adult; Aged; Aged, 80 and over; Cost-Benefit Analysis; Female; *Health Care Costs; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Paclitaxel; *Safety; Time Factors


Pharmacy and Pharmaceutical Sciences


This study challenges the current practice of administering paclitaxel for a variety of malignancies over 3 hours and documents the safety and cost-effectiveness of 1-hour administration in the outpatient setting. The authors investigated opportunities to save nursing time and costs in a cancer clinic without compromising patient safety. These savings are referred to as "opportunity-cost savings" that enable the clinic to schedule more patients during the time normally required to administer a 3-hour paclitaxel dose. Over a 2-year period, the authors were able to document significant time savings with no increase in adverse drug reactions.

Rights and Permissions

Citation: J Infus Nurs. 2004 Jul-Aug;27(4):251-3.

Related Resources

Link to Article in PubMed

PubMed ID