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Adam O. Whelan, Helen C. Flick-Smith, Jane Homan, Zu T. Shen, Zoe Carpenter, Payam Khoshkenar, Ambily Abraham, Nicola J. Walker, Stuart M. Levitz, Gary R. Ostroff, Petra C. F. Oyston
Protection induced by a Francisella tularensis subunit vaccine delivered by glucan particles
www.plosone.org
www.plosone.org
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(in-house.)Tj
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Q
q
0.45 0.36 0.35 0.01 k
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1 J
0 w
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200.0001 488.5705 l
f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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349.852 305.9717 m
355.578 305.9717 l
h
f*
440.5606 255.9685 m
446.2866 255.9685 l
h
f*
447.6472 255.9685 m
453.4299 255.9685 l
h
f*
456.548 255.9685 m
462.274 255.9685 l
h
f*
373.5496 243.4961 m
379.2756 243.4961 l
h
f*
380.6929 243.4961 m
386.4189 243.4961 l
h
f*
378.7087 230.9669 m
384.4346 230.9669 l
h
f*
385.7953 230.9669 m
391.578 230.9669 l
h
f*
359.3197 218.4945 m
365.1024 218.4945 l
h
f*
366.463 218.4945 m
372.189 218.4945 l
h
f*
423.8362 193.4929 m
429.6189 193.4929 l
h
f*
430.9795 193.4929 m
436.7055 193.4929 l
h
f*
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369.1843 134.022 l
h
f*
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350.7591 93.9969 l
h
f*
0 g
7.9999 0 0 7.9999 200.0125 493.9086 cm
BT
/F15 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(1.)Tj
/F16 1 Tf
1.1763 0 Td
[()]TJ
/F15 1 Tf
(.)Tj
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0.9993 0 Td
[()-2()2()-1()12()8()-7()-10( )6(\n)-13( )]TJ
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(antigens)Tj
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(tested.)Tj
0 Tc
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(Putative)Tj
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(Functi)Tj
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(on)Tj
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-17.7308 -1.559 Td
(FTT0071)Tj
8.0221 0 Td
(Citrate)Tj
3.0047 0 Td
(synthase)Tj
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(,)Tj
0.4606 0 Td
(GltA)Tj
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(FTT0143)Tj
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(L7/L12)Tj
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(50S)Tj
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(ribosomal)Tj
4.2662 0 Td
(protein)Tj
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(FTT0209)Tj
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(Homology)Tj
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(with)Tj
2.0126 0 Td
(pneumoco)Tj
4.2874 0 Td
(ccal)Tj
1.7717 0 Td
(surface)Tj
3.0756 0 Td
(antigen)Tj
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(A,)Tj
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(PsaA)Tj
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(FTT0239)Tj
8.0221 0 Td
(MurC)Tj
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(/)Tj
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(UDP-N-acet)Tj
5.067 0 Td
(yl-muramat)Tj
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(e:alanine)Tj
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(ligase)Tj
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(FTT0289)Tj
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(Putative)Tj
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(lipoprot)Tj
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(ein)Tj
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(unknown)Tj
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(function)Tj
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(FTT0374)Tj
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(CTP)Tj
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(synthase)Tj
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(FTT0438)Tj
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(UDP-N-acet)Tj
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(ylmuramat)Tj
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(e:L-alanyl-gam)Tj
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(ma-D-glutam)Tj
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(yl-meso-dia)Tj
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(minopimelat)Tj
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(e)Tj
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(ligase)Tj
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(/murein)Tj
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(peptide)Tj
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(FTT0464)Tj
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(L-asparagina)Tj
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(se)Tj
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(II)Tj
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(ansB)Tj
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(/)Tj
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(periplasmi)Tj
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(c)Tj
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(L-asparaginase)Tj
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(II)Tj
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(precurs)Tj
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(FTT0468)Tj
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(Peptidyl-pr)Tj
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(olyl)Tj
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(cis-trans)Tj
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(isomeras)Tj
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(FTT0482)Tj
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(FTT0540)Tj
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(FTT0547)Tj
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(FTT0721)Tj
8.0221 0 Td
(Catalase)Tj
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(peroxidas)Tj
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(e,)Tj
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(KatG)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F9 1 Tf
1 TL
0 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(])Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 200.0125 294.5763 cm
BT
/F9 1 Tf
1 TL
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(FTT0724)Tj
8.0221 0 Td
(Penicillin)Tj
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(binding)Tj
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(protein)Tj
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(l-D-alanine)Tj
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(carboxypep)Tj
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(tidase\))Tj
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(FTT0814)Tj
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(FTT0890)Tj
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(Type)Tj
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(IV)Tj
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(pilin)Tj
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(protein,)Tj
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(PilA)Tj
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(FTT0901)Tj
8.0221 0 Td
(Outer)Tj
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(membran)Tj
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(e)Tj
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(17)Tj
1.1835 0 Td
(kDa)Tj
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(lipoprot)Tj
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(ein)Tj
1.4811 0 Td
(LpnA)Tj
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(or)Tj
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(Tul4-A)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F9 1 Tf
1 TL
0 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(42)Tj
0 g
()Tj
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(44)Tj
0 g
(])Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 200.0125 244.5732 cm
BT
/F9 1 Tf
1 TL
0 0 Td
(FTT0904)Tj
8.0221 0 Td
(Outer)Tj
2.6079 0 Td
(membran)Tj
3.9331 0 Td
(e)Tj
0.659 0 Td
(protein)Tj
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(Tul4-B)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 371.5086 248.1448 cm
BT
/F9 1 Tf
1 TL
0 0 Td
([)Tj
0.83 0.64 0.02 0 k
(43)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(44)Tj
0 g
(])Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 200.0125 232.044 cm
BT
/F9 1 Tf
1 TL
0 0 Td
(FTT0918)Tj
8.0221 0 Td
(Outer)Tj
2.6079 0 Td
(membran)Tj
3.9331 0 Td
(e)Tj
0.659 0 Td
(protein)Tj
3.1819 0 Td
(YapH-N)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 376.611 235.6157 cm
BT
/F9 1 Tf
1 TL
0 0 Td
([)Tj
0.83 0.64 0.02 0 k
(43)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(44)Tj
0 g
(])Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 200.0125 219.5716 cm
BT
/F9 1 Tf
1 TL
0 0 Td
(FTT1043)Tj
8.0221 0 Td
(Macrophage)Tj
5.2441 0 Td
(infectivity,)Tj
4.4788 0 Td
(Mip)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 357.2787 223.1433 cm
BT
/F9 1 Tf
1 TL
0 0 Td
([)Tj
0.83 0.64 0.02 0 k
(43)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(44)Tj
0 g
(])Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 200.0125 207.0992 cm
BT
/F9 1 Tf
1 TL
0 0 Td
(FTT1161)Tj
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