UMMS Affiliation
Department of Cell Biology
Publication Date
2-24-2009
Document Type
Article
Subjects
Animals; Cell Lineage; Cell Nucleus; Cell Proliferation; *Epigenesis, Genetic; Humans; Mitosis; Transcription Factors
Disciplines
Cell Biology
Abstract
Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.
Rights and Permissions
Copyright NRC Research Press.
DOI of Published Version
10.1139/o08-094
Source
Biochem Cell Biol. 2009 Feb;87(1):1-6. Link to article on publisher's site
Journal/Book/Conference Title
Biochemistry and cell biology = Biochimie et biologie cellulaire
Related Resources
PubMed ID
19234518
Repository Citation
Stein, Gary S.; Zaidi, Sayyed K.; Stein, Janet L.; Lian, Jane B.; Van Wijnen, Andre J.; Montecino, Martin A.; Young, Daniel W.; Javed, Amjad; Pratap, Jitesh; Choi, Je-Yong; Ali, Syed A.; Pande, Sandhya; and Hassan, Mohammad Q., "Transcription-factor-mediated epigenetic control of cell fate and lineage commitment" (2009). Cell and Developmental Biology Publications. 89.
https://escholarship.umassmed.edu/cellbiology_pp/89