Department of Cell Biology
Animals; Cell Lineage; Cell Nucleus; Cell Proliferation; *Epigenesis, Genetic; Humans; Mitosis; Transcription Factors
Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.
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Copyright NRC Research Press.
DOI of Published Version
Biochem Cell Biol. 2009 Feb;87(1):1-6. Link to article on publisher's site
Biochemistry and cell biology = Biochimie et biologie cellulaire
Stein GS, Zaidi SK, Stein JL, Lian JB, Van Wijnen AJ, Montecino MA, Young DW, Javed A, Pratap J, Choi J, Ali SA, Pande S, Hassan MQ. (2009). Transcription-factor-mediated epigenetic control of cell fate and lineage commitment. Cell and Developmental Biology Publications. https://doi.org/10.1139/o08-094. Retrieved from https://escholarship.umassmed.edu/cellbiology_pp/89