Title

Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer

UMMS Affiliation

Department of Cell Biology

Publication Date

2009-03-03

Document Type

Article

Subjects

Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; *Epigenesis, Genetic; Gene Expression; Humans; Mitosis; Transcription Factors; Transcription, Genetic

Disciplines

Cell Biology

Abstract

There is growing awareness that the fidelity of gene expression necessitates coordination of transcription factor metabolism and organization of genes and regulatory proteins within the three-dimensional context of nuclear architecture. The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis. High throughput imaging of cells, tissues, and tumors, including live cell analysis, is expanding research's capabilities toward translating components of nuclear organization into novel strategies for cancer diagnosis and therapy.

DOI of Published Version

10.1111/j.1749-6632.2009.03697.x

Source

Ann N Y Acad Sci. 2009 Feb;1155:4-14. Link to article on publisher's site

Journal/Book/Conference Title

Annals of the New York Academy of Sciences

Related Resources

Link to Article in PubMed

PubMed ID

19250187

Link to Full Text

Share

COinS