The Chlamydomonas genome reveals the evolution of key animal and plant functions

UMMS Affiliation

Department of Cell Biology; Program in Molecular Medicine



Document Type



Algal Proteins; Animals; Chlamydomonas reinhardtii; Chloroplasts; Computational Biology; DNA, Algal; *Evolution; Flagella; Genes; *Genome; Genomics; Membrane Transport Proteins; Molecular Sequence Data; Multigene Family; Photosynthesis; Phylogeny; Plants; Proteome; Sequence Analysis, DNA


Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the approximately 120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.

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Citation: Science. 2007 Oct 12;318(5848):245-50. Link to article on publisher's site


See the article on publisher's site or in PubMed Central for the full list of authors.

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Link to Article in PubMed

Journal Title

Science (New York, N.Y.)

PubMed ID