Title

Intraflagellar transport

UMMS Affiliation

Department of Cell Biology

Publication Date

2002-11-05

Document Type

Article

Subjects

Animals; Biological Transport; Cilia; Flagella; Humans; Polycystic Kidney Diseases; Retinal Degeneration; Signal Transduction

Disciplines

Cell Biology

Abstract

Eukaryotic cilia and flagella, including primary cilia and sensory cilia, are highly conserved organelles that project from the surfaces of many cells. The assembly and maintenance of these nearly ubiquitous structures are dependent on a transport system--known as 'intraflagellar transport' (IFT)--which moves non-membrane-bound particles from the cell body out to the tip of the cilium or flagellum, and then returns them to the cell body. Recent results indicate that defects in IFT might be a primary cause of some human diseases.

DOI of Published Version

10.1038/nrm952

Source

Nat Rev Mol Cell Biol. 2002 Nov;3(11):813-25. Link to article on publisher's site

Journal/Book/Conference Title

Nature reviews. Molecular cell biology

Related Resources

Link to Article in PubMed

PubMed ID

12415299

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