Title

Rotation of the central pair microtubules in eukaryotic flagella

UMMS Affiliation

Department of Cell Biology

Publication Date

1999-01-08

Document Type

Article

Subjects

Algae; Animals; Chlamydomonas reinhardtii; Flagella; Male; Microscopy, Video; Microtubules; Rotation; Sea Urchins; Sperm Tail

Disciplines

Amino Acids, Peptides, and Proteins | Cell Biology | Cells | Enzymes and Coenzymes | Investigative Techniques

Abstract

The typical structure of the eukaryotic flagellum consists of a central pair of singlet microtubules surrounded by nine doublet microtubules, called the axoneme. Much has been discovered regarding the mechanism by which axonemes produce motion: ATP is used by dynein arms found on the A tubules of the doublet microtubules to produce shear force against the B tubules. These shear forces are then converted to bending. However, if all the dynein arms along the length of the axoneme and on all doublets attempted to produce shear simultaneously, no effective movement would result. Thus, regulation of active shear force is required. Evidence suggests that the central pair–radial spoke complex is involved in this regulation. The first evidence came from an electron micrograph study in which the central pair microtubules of Paramecium, “instantaneously fixed” and serially sectioned, appeared to be oriented in systematically changing angles. This was interpreted as rotation of the central pair with respect to the nine outer doublets per beat cycle (Omoto and Kung, 1979 , 1980 ). It was suggested that the central pair may act as a “distributor” to regulate the activity of dyneins.

DOI of Published Version

10.1091/mbc.10.1.1

Source

Mol Biol Cell. 1999 Jan;10(1):1-4.

Journal/Book/Conference Title

Molecular biology of the cell

Related Resources

Link to Article in PubMed

PubMed ID

9880321

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