YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis
Department of Cell and Developmental Biology; Department of Microbiology and Physiological Systems
Cell Biology | Immunity
The germinal center (GC) reaction produces high-affinity Abs for a robust adaptive immune response. When dysregulated, the same processes cause GC B cells to become susceptible to lymphomagenesis. It is important to understand how the GC reaction is regulated. In this study, we show that transcription factor YY1 is required to maintain a robust GC reaction in mice. Selective ablation of YY1 significantly decreased in the frequency and number of GC B cells during the GC reaction. This decrease of GC B cells was accompanied by increased apoptosis in these cells. Furthermore, we found that loss of YY1 disrupted the balance between dark zones and light zones, leading to a preferential decrease in dark zone cells. Collectively, these results indicate that YY1 plays an important role in regulating the balance between dark zone and light zone cells in GCs and between survival and death of GC B cells.
DOI of Published Version
J Immunol. 2016 Sep 1;197(5):1699-707. doi: 10.4049/jimmunol.1600721. Epub 2016 Jul 22. Link to article on publisher's site
Journal of immunology (Baltimore, Md. : 1950)
Trabucco SE, Gerstein RM, Zhang H. (2016). YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis. Cell and Developmental Biology Publications. https://doi.org/10.4049/jimmunol.1600721. Retrieved from https://escholarship.umassmed.edu/cellbiology_pp/193