Department of Cell and Developmental Biology
Cell and Developmental Biology | Cell Biology | Genetics | Musculoskeletal Diseases
The analysis of individuals with ciliary chondrodysplasias can shed light on sensitive mechanisms controlling ciliogenesis and cell signalling that are essential to embryonic development and survival. Here we identify TCTEX1D2 mutations causing Jeune asphyxiating thoracic dystrophy with partially penetrant inheritance. Loss of TCTEX1D2 impairs retrograde intraflagellar transport (IFT) in humans and the protist Chlamydomonas, accompanied by destabilization of the retrograde IFT dynein motor. We thus define TCTEX1D2 as an integral component of the evolutionarily conserved retrograde IFT machinery. In complex with several IFT dynein light chains, it is required for correct vertebrate skeletal formation but may be functionally redundant under certain conditions.
Biological sciences, Cell biology, Genetics
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DOI of Published Version
Nat Commun. 2015 Jun 5;6:7074. doi: 10.1038/ncomms8074. Link to article on publisher's site
Schmidts M, Hou Y, Mitchison HM, Witman GB. (2015). TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport. Cell and Developmental Biology Publications. https://doi.org/10.1038/ncomms8074. Retrieved from https://escholarship.umassmed.edu/cellbiology_pp/171
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.