Extra-embryonic Wnt3 regulates the establishment of the primitive streak in mice

UMMS Affiliation

Department of Cell and Developmental Biology



Document Type



Animals; Body Patterning; Endoderm; Gastrulation; Gene Expression Regulation, Developmental; Mice; Primitive Streak; Wnt3 Protein


The establishment of the head to tail axis at early stages of development is a fundamental aspect of vertebrate embryogenesis. In mice, experimental embryology, genetics and expression studies have suggested that the visceral endoderm, an extra-embryonic tissue, plays an important role in anteroposterior axial development. Here we show that absence of Wnt3 in the posterior visceral endoderm leads to delayed formation of the primitive streak and that interplay between anterior and posterior visceral endoderm restricts the position of the primitive streak. Embryos lacking Wnt3 in the visceral endoderm, however, appear normal by E9.5. Our results suggest a model for axial development in which multiple signals are required for anteroposterior axial development in mammals.

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Citation: Dev Biol. 2015 Jul 1;403(1):80-8. doi: 10.1016/j.ydbio.2015.04.008. Link to article on publisher's site.

Related Resources

Link to Article in PubMed


Axial specification, Embryo, Gastrulation, Mouse, Primitive streak, Wnt3

Journal Title

Developmental biology

PubMed ID