Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus
Department of Cell and Developmental Biology; UMass Metabolic Network
Biochemistry | Cell Biology | Molecular Biology
The organization of interphase chromosomes in chromosome territories (CTs) was first proposed more than one hundred years ago. The introduction of increasingly sophisticated microscopic and molecular techniques, now provide complementary strategies for studying CTs in greater depth than ever before. Here we provide an overview of these strategies and how they are being used to elucidate CT interactions and the role of these dynamically regulated, nuclear-structure building blocks in directly supporting nuclear function in a physiologically responsive manner. This article is protected by copyright.
DOI of Published Version
J Cell Biochem. 2015 Jul 20. doi: 10.1002/jcb.25280. Link to article on publisher's site.
Journal of cellular biochemistry
Fritz, Andrew; Barutcu, Rasim; Martin-Buley, Lori; van Wijnen, Andre J.; Zaidi, Sayyed K.; Imbalzano, Anthony N.; Lian, Jane B.; Stein, Janet L.; and Stein, Gary S., "Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus" (2015). Cell and Developmental Biology Publications. 163.