Title

Bookmarking the genome: maintenance of epigenetic information

UMMS Affiliation

Department of Cell Biology

Publication Date

5-27-2011

Document Type

Article

Subjects

Epigenesis, Genetic

Disciplines

Cell Biology

Abstract

Mitotic inheritance of gene function is obligatory to sustain biological control. Emerging evidence suggests that epigenetic mechanisms are linked to transmission of cell fate, lineage commitment, and maintenance of cellular phenotype in progeny cells. Mechanisms of epigenetic memory include gene silencing by DNA methylation, transcriptional regulation by histone modifications, regulation of gene expression by noncoding small RNA molecules, and retention of regulatory machinery on target gene loci for activation and repression. We will focus on the regulatory implications of epigenetic memory for physiological control and for the onset and progression of disease.

DOI of Published Version

10.1074/jbc.R110.197061

Source

J Biol Chem. 2011 May 27;286(21):18355-61. Epub 2011 Mar 24. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of biological chemistry

Related Resources

Link to Article in PubMed

PubMed ID

21454629

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