The Simple Arithmetic of Mixed Aortic Valve Disease: LVH + Volume Load = Trouble
Division of Cardiovascular Medicine, Department of Medicine
Cardiology | Cardiovascular Diseases
Aortic stenosis (AS) is the prototypical pressure overload lesion. The Gunther-Grossman paradigm of the 1970s dictates that as afterload increases, concentric hypertrophy—increases in left ventricular (LV) mass index and relative wall thickness—normalize systolic load and allow for normal ejection fraction despite markedly increased intraventricular systolic pressure. In some individuals, this compensatory process appears to be excessive and can be associated with poor outcome even with aortic valve replacement (AVR). Increasingly, attention has been focused on the malefic consequences for diastolic function of such ‘compensatory’ hypertrophy.
adverse events, aortic regurgitation, aortic stenosis, mixed aortic valve disease
DOI of Published Version
J Am Coll Cardiol. 2016 May 24;67(20):2330-2333. doi: 10.1016/j.jacc.2016.03.549. Link to article on publisher's site
Journal of the American College of Cardiology
Parker, Matthew and Aurigemma, Gerard P., "The Simple Arithmetic of Mixed Aortic Valve Disease: LVH + Volume Load = Trouble" (2016). Cardiovascular Medicine Publications and Presentations. 98.