Title

The Simple Arithmetic of Mixed Aortic Valve Disease: LVH + Volume Load = Trouble

UMMS Affiliation

Division of Cardiovascular Medicine, Department of Medicine

Publication Date

2016-05-24

Document Type

Editorial

Disciplines

Cardiology | Cardiovascular Diseases

Abstract

Aortic stenosis (AS) is the prototypical pressure overload lesion. The Gunther-Grossman paradigm of the 1970s dictates that as afterload increases, concentric hypertrophy—increases in left ventricular (LV) mass index and relative wall thickness—normalize systolic load and allow for normal ejection fraction despite markedly increased intraventricular systolic pressure. In some individuals, this compensatory process appears to be excessive and can be associated with poor outcome even with aortic valve replacement (AVR). Increasingly, attention has been focused on the malefic consequences for diastolic function of such ‘compensatory’ hypertrophy.

Keywords

adverse events, aortic regurgitation, aortic stenosis, mixed aortic valve disease

DOI of Published Version

10.1016/j.jacc.2016.03.549

Source

J Am Coll Cardiol. 2016 May 24;67(20):2330-2333. doi: 10.1016/j.jacc.2016.03.549. Link to article on publisher's site

Journal/Book/Conference Title

Journal of the American College of Cardiology

Related Resources

Link to Article in PubMed

PubMed ID

27199055

Share

COinS