C'est LAVi: What Left Atrial Dilatation Tells Us About Diastolic Function in Aortic Stenosis

UMMS Affiliation

Division of Cardiovascular Medicine, Department of Medicine

Publication Date


Document Type



Cardiology | Cardiovascular Diseases | Geriatrics | Pathological Conditions, Signs and Symptoms | Surgical Procedures, Operative | Therapeutics


Calcific degenerative aortic valve stenosis (AS) is the most common acquired form of heart valve disease that afflicts the elderly population1 and usually comes to attention when an echocardiogram is ordered to evaluate a systolic murmur in an older subject. As is evident to anyone practicing cardiology these days, the advent of transcatheter aortic valve replacement has focused much attention on the evaluation and optimal treatment of patients with AS. AS often has a long latency period in which symptoms are absent, and, importantly, sudden unexpected cardiac death is rare.2,3 With symptom onset, survival is markedly reduced without intervention.46 For symptomatic patients with severe AS and normal flow-high gradient characteristics and normal left ventricular ejection fraction (LVEF) (stage D1), aortic valve replacement (AVR) is a class 1 indication. Similarly, for asymptomatic patients with severe AS and LVEF less than fifty percent not because of another cause (stage C2), AVR also is indicated.


Editorials, aortic valve stenosis, echocardiography, heart valve disease, hemodynamics, left atrium, systolic murmur

DOI of Published Version



Circ Cardiovasc Imaging. 2016 Oct;9(10). pii: e005683. 10.1161/CIRCIMAGING.116.005683. Link to article on publisher's site

Journal/Book/Conference Title

Circulation. Cardiovascular imaging

Related Resources

Link to Article in PubMed

PubMed ID