Vitamin D intake from foods and supplements and depressive symptoms in a diverse Population of Older Women.
Department of Medicine, Division of Cardiovascular Medicine; Department of Medicine, Division of Preventive and Behavioral Medicine
Vitamin D; Depression; Postmenopause; Women
Cardiology | Cardiovascular Diseases | Dietetics and Clinical Nutrition | Epidemiology | Geriatrics | Mental Disorders | Musculoskeletal, Neural, and Ocular Physiology | Polycyclic Compounds | Reproductive and Urinary Physiology | Therapeutics | Women's Health
Vitamin D may plausibly reduce the occurrence of depression in postmenopausal women; however, epidemiologic evidence is limited, and few prospective studies have been conducted.
We conducted a cross-sectional and prospective analysis of vitamin D intake from foods and supplements and risk of depressive symptoms.
Study participants were 81,189 members of the Women's Health Initiative (WHI) Observational Study who were aged 50-79 y at baseline. Vitamin D intake at baseline was measured by food-frequency and supplement-use questionnaires. Depressive symptoms at baseline and after 3 y were assessed by using the Burnam scale and current antidepressant medication use.
After age, physical activity, and other factors were controlled for, women who reported a total intake of ≥800 IU vitamin D/d had a prevalence OR for depressive symptoms of 0.79 (95% CI: 0.71, 0.89; P-trend < 0.001) compared with women who reported a total intake of
Overall, our findings support a potential inverse association of vitamin D, primarily from food sources, and depressive symptoms in postmenopausal women. Additional prospective studies and randomized trials are essential in establishing whether the improvement of vitamin D status holds promise for the prevention of depression, the treatment of depression, or both.
physical activity, antidepressive agents, depressive disorders, food, vitamin d, elderly
DOI of Published Version
American Journal of Clinical Nutrition. 2011 Aug 24, doi: 10.3945/ajcn.111.017384. To be published in the October 2011 issue of American Journal of Clinical Nutrition.
American journal of clinical nutrition
Bertone-Johnson E, Powers SI, Spangler L, Brunner RL, Michael YL, Larson JC, Millen AE, Bueche MN, Salmoirago Blotcher E, Liu S, Wassertheil-Smoller S, Ockene JK, Ockene IS, Manson JE. (2011). Vitamin D intake from foods and supplements and depressive symptoms in a diverse Population of Older Women.. Cardiovascular Medicine Publications. https://doi.org/10.3945/ajcn.111.017384. Retrieved from https://escholarship.umassmed.edu/cardio_pp/80