Title

Vitamin D intake from foods and supplements and depressive symptoms in a diverse Population of Older Women.

UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine; Department of Medicine, Division of Preventive and Behavioral Medicine

Publication Date

2011-08-24

Document Type

Article

Subjects

Vitamin D; Depression; Postmenopause; Women

Disciplines

Cardiology | Cardiovascular Diseases | Dietetics and Clinical Nutrition | Epidemiology | Geriatrics | Mental Disorders | Musculoskeletal, Neural, and Ocular Physiology | Polycyclic Compounds | Reproductive and Urinary Physiology | Therapeutics | Women's Health

Abstract

BACKGROUND:

Vitamin D may plausibly reduce the occurrence of depression in postmenopausal women; however, epidemiologic evidence is limited, and few prospective studies have been conducted.

OBJECTIVE:

We conducted a cross-sectional and prospective analysis of vitamin D intake from foods and supplements and risk of depressive symptoms.

DESIGN:

Study participants were 81,189 members of the Women's Health Initiative (WHI) Observational Study who were aged 50-79 y at baseline. Vitamin D intake at baseline was measured by food-frequency and supplement-use questionnaires. Depressive symptoms at baseline and after 3 y were assessed by using the Burnam scale and current antidepressant medication use.

RESULTS:

After age, physical activity, and other factors were controlled for, women who reported a total intake of ≥800 IU vitamin D/d had a prevalence OR for depressive symptoms of 0.79 (95% CI: 0.71, 0.89; P-trend < 0.001) compared with women who reported a total intake of

CONCLUSIONS:

Overall, our findings support a potential inverse association of vitamin D, primarily from food sources, and depressive symptoms in postmenopausal women. Additional prospective studies and randomized trials are essential in establishing whether the improvement of vitamin D status holds promise for the prevention of depression, the treatment of depression, or both.

Keywords

physical activity, antidepressive agents, depressive disorders, food, vitamin d, elderly

DOI of Published Version

10.3945/ajcn.111.017384

Source

American Journal of Clinical Nutrition. 2011 Aug 24, doi: 10.3945/ajcn.111.017384. To be published in the October 2011 issue of American Journal of Clinical Nutrition.

Journal/Book/Conference Title

American journal of clinical nutrition

Related Resources

Link to article in PubMed

PubMed ID

21865327

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