Why not routinely use best linear unbiased predictors (BLUPs) as estimates of cholesterol, per cent fat from kcal and physical activity
UMass Chan Affiliations
Department of Medicine, Division of Cardiovascular MedicineDocument Type
Journal ArticlePublication Date
1999-10-19Keywords
AdultAged
Cholesterol
*Computer Simulation
Dietary Fats
Exercise
Female
Humans
Male
Metabolism
Middle Aged
*Models, Cardiovascular
*Models, Statistical
*Predictive Value of Tests
Cardiology
Cardiovascular Diseases
Diagnosis
Lipids
Polycyclic Compounds
Metadata
Show full item recordAbstract
Measures of biologic and behavioural variables on a patient often estimate longer term latent values, with the two connected by a simple response error model. For example, a subject's measured total cholesterol is an estimate (equal to the best linear unbiased estimate (BLUE)) of a subject's latent total cholesterol. With known (or estimated) variances, an alternative estimate is the best linear unbiased predictor (BLUP). We illustrate and discuss when the BLUE or BLUP will be a better estimate of a subject's latent value given a single measure on a subject, concluding that the BLUP estimator should be routinely used for total cholesterol and per cent kcal from fat, with a modified BLUP estimator used for large observed values of leisure time activity. Data from a large longitudinal study of seasonal variation in serum cholesterol forms the backdrop for the illustrations. Simulations which mimic the empirical and response error distributions are used to guide choice of an estimator. We use the simulations to describe criteria for estimator choice, to identify parameter ranges where BLUE or BLUP estimates are superior, and discuss key ideas that underlie the results.Source
Stat Med. 1999 Nov 15;18(21):2943-59.
DOI
10.1002/(SICI)1097-0258(19991115)18:21<2943::AID-SIM241>3.0.CO;2-0Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26390PubMed ID
10523752Related Resources
ae974a485f413a2113503eed53cd6c53
10.1002/(SICI)1097-0258(19991115)18:21<2943::AID-SIM241>3.0.CO;2-0