Authors
Fisher, MarcWeiner, Bonnie H.
Ockene, Ira S.
Forsberg, Ann D.
Duffy, Celeste P.
Levine, Peter H.
UMass Chan Affiliations
Department of Medicine, Division of Cardiovascular MedicineDepartment of Neurology
Document Type
Journal ArticlePublication Date
1983-03-01Keywords
AdolescentAdult
Aged
Blood Coagulation Factors
Blood Platelets
Cerebrovascular Disorders
Female
Humans
Male
Middle Aged
Mitral Valve Prolapse
Platelet Factor 4
Risk
Hemostasis
F1+2
P-selectin
platelets
mitral valve prolapse
Cardiology
Cardiovascular Diseases
Cells
Diagnosis
Hemic and Immune Systems
Metadata
Show full item recordAbstract
Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults. Cerebral embolization of intracardiac thrombi is the probable mechanism in many cases. Platelets play a key role in the development of thrombi. We found that platelet factor 4, a marker protein of platelet activation, was elevated in 12 of 33 MVP patients (36%) without a history of stroke. This finding indicates that platelets are frequently activated in asymptomatic MVP patients and may allow identification of a subgroup of MVP patients with activated platelets who are at increased risk for emboli.Source
Neurology. 1983 Mar;33(3):384-6.
DOI
10.1212/wnl.33.3.384Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26344PubMed ID
6681886Related Resources
ae974a485f413a2113503eed53cd6c53
10.1212/wnl.33.3.384