Platelet activation and mitral valve prolapse
Department of Neurology; Department of Medicine, Division of Cardiovascular Medicine
Adolescent; Adult; Aged; Blood Coagulation Factors; Blood Platelets; Cerebrovascular Disorders; Female; Humans; Male; Middle Aged; Mitral Valve Prolapse; Platelet Factor 4; Risk
Cardiology | Cardiovascular Diseases
Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults. Cerebral embolization of intracardiac thrombi is the probable mechanism in many cases. Platelets play a key role in the development of thrombi. We found that platelet factor 4, a marker protein of platelet activation, was elevated in 12 of 33 MVP patients (36%) without a history of stroke. This finding indicates that platelets are frequently activated in asymptomatic MVP patients and may allow identification of a subgroup of MVP patients with activated platelets who are at increased risk for emboli.
Neurology. 1983 Mar;33(3):384-6.
Fisher, Marc; Weiner, Bonnie H.; Ockene, Ira S.; Forsberg, Ann D.; Duffy, Celeste P.; and Levine, Peter H., "Platelet activation and mitral valve prolapse" (1983). Cardiovascular Medicine Publications and Presentations. 24.