Platelet activation and mitral valve prolapse
Department of Neurology; Department of Medicine, Division of Cardiovascular Medicine
Adolescent; Adult; Aged; Blood Coagulation Factors; Blood Platelets; Cerebrovascular Disorders; Female; Humans; Male; Middle Aged; Mitral Valve Prolapse; Platelet Factor 4; Risk
Cardiology | Cardiovascular Diseases | Cells | Diagnosis | Hemic and Immune Systems
Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults. Cerebral embolization of intracardiac thrombi is the probable mechanism in many cases. Platelets play a key role in the development of thrombi. We found that platelet factor 4, a marker protein of platelet activation, was elevated in 12 of 33 MVP patients (36%) without a history of stroke. This finding indicates that platelets are frequently activated in asymptomatic MVP patients and may allow identification of a subgroup of MVP patients with activated platelets who are at increased risk for emboli.
Hemostasis, F1+2, P-selectin, platelets, mitral valve prolapse
DOI of Published Version
Neurology. 1983 Mar;33(3):384-6.
Fisher M, Weiner BH, Ockene IS, Forsberg AD, Duffy CP, Levine PH. (1983). Platelet activation and mitral valve prolapse. Cardiovascular Medicine Publications. https://doi.org/10.1212/wnl.33.3.384. Retrieved from https://escholarship.umassmed.edu/cardio_pp/24