Platelet activation and mitral valve prolapse

UMMS Affiliation

Department of Neurology; Department of Medicine, Division of Cardiovascular Medicine



Document Type



Adolescent; Adult; Aged; Blood Coagulation Factors; Blood Platelets; Cerebrovascular Disorders; Female; Humans; Male; Middle Aged; Mitral Valve Prolapse; Platelet Factor 4; Risk


Cardiology | Cardiovascular Diseases


Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults. Cerebral embolization of intracardiac thrombi is the probable mechanism in many cases. Platelets play a key role in the development of thrombi. We found that platelet factor 4, a marker protein of platelet activation, was elevated in 12 of 33 MVP patients (36%) without a history of stroke. This finding indicates that platelets are frequently activated in asymptomatic MVP patients and may allow identification of a subgroup of MVP patients with activated platelets who are at increased risk for emboli.

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Citation: Neurology. 1983 Mar;33(3):384-6.

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Link to article in PubMed

PubMed ID