Title
Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults
UMMS Affiliation
Department of Medicine, Division of Cardiovascular Medicine; Department of Medicine, Division of Preventive and Behavorial Medicine
Publication Date
2001-03-10
Document Type
Article
Subjects
Adult; Aged; Analysis of Variance; C-Reactive Protein; Cholesterol; Female; Humans; Immunoassay; Longitudinal Studies; Male; Middle Aged; Nephelometry and Turbidimetry; Reference Values; Sex Factors
Disciplines
Cardiology | Cardiovascular Diseases
Abstract
BACKGROUND: Increased concentrations of high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, are associated with increased risk for coronary heart disease. Because of its relationship to inflammation, hs-CRP has considerable biologic variation. This study was carried out to characterize CRP variation and to compare it to another risk factor, total serum cholesterol.
METHODS: One hundred thirteen individuals were scheduled to have five measurements each of hs-CRP and total cholesterol carried out at quarterly intervals over a 1-year period. Variations of hs-CRP and total cholesterol were characterized, and classification accuracy was described and compared for both.
RESULTS: The relative variation was comparable for hs-CRP and total cholesterol. When classified by quartile, 63% of first and second hs-CRP measurements were in agreement; for total cholesterol it was 60%. Ninety percent of hs-CRP measurements were within one quartile of each other. This relationship was not altered by the use of log-transformed hs-CRP data.
CONCLUSION: hs-CRP has a degree of measurement stability that is similar to that of total cholesterol.
Source
Clin Chem. 2001 Mar;47(3):444-50.
Journal/Book/Conference Title
Clinical chemistry
Related Resources
PubMed ID
11238295
Repository Citation
Ockene IS, Matthews CE, Rifai N, Ridker PM, Reed GW, Stanek EJ. (2001). Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults. Cardiovascular Medicine Publications. Retrieved from https://escholarship.umassmed.edu/cardio_pp/18