Evidence for a Ras/Ral signaling cascade
Department of Cancer Biology
Animals; Cell Cycle Proteins; GTP-Binding Proteins; Phospholipase D; *Signal Transduction; cdc42 GTP-Binding Protein, Saccharomyces cerevisiae; rac GTP-Binding Proteins; rap GTP-Binding Proteins; ras Proteins
Cancer Biology | Neoplasms
It is becoming clear that Ras proteins mediate their diverse biological functions by binding to, and participating in, the activation of multiple downstream targets. Recent work has identified nucleotide-exchange factors for Ral-GTPases as the newest members of the set of putative Ras 'effector molecules'. This new work has also detected two potential downstream targets of Ral proteins, a novel CDC42/Rac GTPase-activating protein and a phospholipase D.
Trends Biochem Sci. 1996 Nov;21(11):438-41.
Trends in biochemical sciences
Feig, Larry A.; Urano, Takeshi; and Cantor, Sharon B., "Evidence for a Ras/Ral signaling cascade" (1996). Cancer Biology Publications and Presentations. 8.