Title

Role of JNK in mammary gland development and breast cancer

UMMS Affiliation

Program in Molecular Medicine; Department of Cancer Biology

Publication Date

2012-01-15

Document Type

Article

Disciplines

Biochemistry | Cancer Biology | Cell Biology | Developmental Biology | Molecular Biology | Neoplasms

Abstract

cJun NH(2)-terminal kinase (JNK) signaling has been implicated in the developmental morphogenesis of epithelial organs. In this study, we employed a compound deletion of the murine Jnk1 and Jnk2 genes in the mammary gland to evaluate the requirement for these ubiquitously expressed genes in breast development and tumorigenesis. JNK1/2 was not required for breast epithelial cell proliferation or motility. However, JNK1/2 deficiency caused increased branching morphogenesis and defects in the clearance of lumenal epithelial cells. In the setting of breast cancer development, JNK1/2 deficiency significantly increased tumor formation. Together, these findings established that JNK signaling is required for normal mammary gland development and that it has a suppressive role in mammary tumorigenesis.

DOI of Published Version

10.1158/0008-5472.CAN-11-1628

Source

Cancer Res. 2012 Jan 15;72(2):472-81. Epub 2011 Nov 29. Link to article on publisher's site

Journal/Book/Conference Title

Cancer research

Related Resources

Link to Article in PubMed

PubMed ID

22127926

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