Role of JNK in mammary gland development and breast cancer
Program in Molecular Medicine; Department of Cancer Biology
Biochemistry | Cancer Biology | Cell Biology | Developmental Biology | Molecular Biology | Neoplasms
cJun NH(2)-terminal kinase (JNK) signaling has been implicated in the developmental morphogenesis of epithelial organs. In this study, we employed a compound deletion of the murine Jnk1 and Jnk2 genes in the mammary gland to evaluate the requirement for these ubiquitously expressed genes in breast development and tumorigenesis. JNK1/2 was not required for breast epithelial cell proliferation or motility. However, JNK1/2 deficiency caused increased branching morphogenesis and defects in the clearance of lumenal epithelial cells. In the setting of breast cancer development, JNK1/2 deficiency significantly increased tumor formation. Together, these findings established that JNK signaling is required for normal mammary gland development and that it has a suppressive role in mammary tumorigenesis.
DOI of Published Version
Cancer Res. 2012 Jan 15;72(2):472-81. Epub 2011 Nov 29. Link to article on publisher's site
Cellurale, Cristina Arrigo; Girnius, Nomeda; Jiang, Feng; Cavanagh-Kyros, Julie; Lu, Shaolei; Garlick, David S.; Mercurio, Arthur M.; and Davis, Roger J., "Role of JNK in mammary gland development and breast cancer" (2012). Cancer Biology Publications and Presentations. 211.