Title
Laminin receptors: achieving specificity through cooperation
UMMS Affiliation
Department of Cancer Biology
Publication Date
1995-11-01
Document Type
Article
Disciplines
Cancer Biology | Neoplasms
Abstract
The laminins are a large family of extracellular matrix proteins that can profoundly influence development, differentiation and disease progression. The biological effects of the laminins are mediated by surface receptors that link laminin matrices to intracellular signalling pathways. Several classes of receptors, including integrins and other molecules, may cooperate to provide the specificity apparent in the diverse array of laminin-mediated phenomena. This review assesses our current understanding of laminin receptors and discusses how such receptors could recognize structural differences among the laminins and relay these differences to the cell.
Source
Trends Cell Biol. 1995 Nov;5(11):419-23.
Journal/Book/Conference Title
Trends in cell biology
Related Resources
PubMed ID
14732046
Repository Citation
Mercurio AM. (1995). Laminin receptors: achieving specificity through cooperation. Cancer Biology Publications and Presentations. Retrieved from https://escholarship.umassmed.edu/cancerbiology_pp/205