Title

IAP regulation of metastasis

UMMS Affiliation

Department of Cancer Biology

Publication Date

2010-02-05

Document Type

Article

Subjects

Animals; Blotting, Western; Cell Line, Tumor; Female; Humans; Inhibitor of Apoptosis Proteins; Male; Mice; Microtubule-Associated Proteins; *Neoplasm Invasiveness; RNA, Small Interfering; Signal Transduction

Disciplines

Cancer Biology | Neoplasms

Abstract

Inhibitor-of-Apoptosis (IAP) proteins contribute to tumor progression, but the requirements of this pathway are not understood. Here, we show that intermolecular cooperation between XIAP and survivin stimulates tumor cell invasion and promotes metastasis. This pathway is independent of IAP inhibition of cell death. Instead, a survivin-XIAP complex activates NF-kappaB, which in turn leads to increased fibronectin gene expression, signaling by beta1 integrins, and activation of cell motility kinases FAK and Src. Therefore, IAPs are direct metastasis genes, and their antagonists could provide antimetastatic therapies in patients with cancer.

DOI of Published Version

10.1016/j.ccr.2009.11.021

Source

Cancer Cell. 2010 Jan 19;17(1):53-64. Link to article on publisher's site

Journal/Book/Conference Title

Cancer cell

Related Resources

Link to Article in PubMed

PubMed ID

20129247

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