Integrin signaling in leukocytes: lessons from the alpha6beta1 integrin
UMass Chan Affiliations
Department of Cancer BiologyDocument Type
Journal ArticlePublication Date
1997-04-01Keywords
AnimalsCell Adhesion
Humans
Integrin alpha6beta1
Integrins
Leukocytes
Signal Transduction
Amino Acids, Peptides, and Proteins
Cancer Biology
Hemic and Immune Systems
Neoplasms
Metadata
Show full item recordAbstract
The adhesive interactions of leukocytes with basement membrane components and other extracellular matrix (ECM) proteins are mediated largely by the integrin family of receptors. These interactions can be regulated by various effector molecules including chemokines, growth factors, and other cell surface proteins by a mechanism termed inside-out signaling of integrin function. On engagement by their ligands, integrins activate a wide range of signaling pathways that regulate a broad array of leukocyte functions such as chemotaxis, cytokine responsiveness, phagocytosis, and gene expression. This review highlights recent advances in the understanding of integrin signaling in leukocytes with an emphasis on our own work on the alpha6beta1 integrin, the major laminin receptor expressed by these cells.Source
J Leukoc Biol. 1997 Apr;61(4):397-407.
DOI
10.1002/jlb.61.4.397Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26233PubMed ID
9103225Related Resources
ae974a485f413a2113503eed53cd6c53
10.1002/jlb.61.4.397