Title
Laminin binding proteins
UMMS Affiliation
Department of Cancer Biology
Publication Date
1991-09-01
Document Type
Article
Subjects
Animals; Cytosol; Integrins; Laminin; Lectins; Neoplasm Proteins; Receptors, Immunologic; Receptors, Laminin; Signal Transduction
Disciplines
Cancer Biology | Neoplasms
Abstract
Cells express many proteins that bind to laminin, the major adhesive component of basement membranes. Some of these, specifically integrins, function as transmembrane receptors that 'signal' the presence of laminin on the cell surface to the cytoplasm. Lectins constitute a second class of laminin binding proteins that may augment integrin function by interacting with laminin carbohydrate. Caution must be used in ascribing functions to other laminin binding proteins, especially cytosolic proteins.
DOI of Published Version
10.1002/bies.950130907
Source
Bioessays. 1991 Sep;13(9):469-73. Link to article on publisher's site
Journal/Book/Conference Title
BioEssays : news and reviews in molecular, cellular and developmental biology
Related Resources
PubMed ID
1839124
Repository Citation
Mercurio AM, Shaw LM. (1991). Laminin binding proteins. Cancer Biology Publications and Presentations. https://doi.org/10.1002/bies.950130907. Retrieved from https://escholarship.umassmed.edu/cancerbiology_pp/121