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Publication Date

2016-02-11

Description

While the majority of cancers are not inherited, there are a number of well described collections of cancers that occur within families. These cancer syndromes were initially identified based on observation of the family history and subsequently the molecular mechanisms have been elucidated. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist is intended to allow the reader to recognize when a pattern of cancers occurs in an individual or their family, and to generate an investigation into potential cancer syndromes. With the rapidly expanding understanding of the molecular basis of cancers at the cellular and constitutional levels, appropriate preventive care may be offered and tailored treatment holds great promise.

Publisher

University of Massachusetts Medical School

City

Worcester, MA

Keywords

Early onset cancer, genetic risk, Knudson’s hypothesis, mutations

Disciplines

Cancer Biology | Medical Genetics | Neoplasms | Oncology

Comments

2nd ed.

This project has been funded in whole or in part with federal funds from the National Library of Medicine, National Institutes of Health, under Contract No. HHSN276201100010C with the University of Massachusetts, Worcester.

Familial Cancer Syndromes

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