This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Biochemistry and Molecular Pharmacology.

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Publications from 2021

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Systematic evaluation of chromosome conformation capture assays, Betul Akgol-Oksuz, Liyan Yang, Sameer Abraham, Sergey V. Venev, Nils Krietenstein, Krishna M. Parsi, Hakan Ozadam, Marlies E. Oomen, Ankita Nand, Hui Mao, Ryan Genga, Rene Maehr, Oliver J. Rando, Leonid A. Mirny, Johan H. Gibcus, and Job Dekker

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INSIGHTS INTO HOW THE 3´UTR MEDIATES EXPRESSION OF A CONSERVED RNA-BINDING PROTEIN AND CONTRIBUTES TO GERMLINE DEVELOPMENT IN C. ELEGANS, Mennatallah M.Y. Albarqi

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The tiny, conserved zinc-finger protein GTSF1 helps PIWI proteins achieve their full catalytic potential [preprint], Amena Arif, Deniz M. Ozata, Cecilia Anderson, Natsuko Izumi, Yukihide Tomari, and Phillip D. Zamore

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Liquid chromatin Hi-C characterizes compartment-dependent chromatin interaction dynamics, Houda Belaghzal, Tyler M. Borrman, Andrew D. Stephens, Denis L. Lafontaine, Sergey V. Venev, Zhiping Weng, John F. Marko, and Job Dekker

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Time-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP [preprint], Christine E. Carbone; Anna B. Loveland; Howard Gamper, Jr.; Ya-Ming Hou; Gabriel Demo; and Andrei A. Korostelev

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The Adaptive Potential of the Middle Domain of Yeast Hsp90, Pamela A. Cote-Hammarlof, Ines Fragata, Julia M. Flynn, David Mavor, Konstantin B. Zeldovich, Claudia Bank, and Daniel N. Bolon

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Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity, William E. Diehl, Mehmet Hakan Guney, Teresa Vanzo, Pyae Phyo Kyawe, Judith M. White, Massimo Pizzato, and Jeremy Luban

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The capacity of origins to load MCM establishes replication timing patterns, Livio Dukaj and Nicholas R. Rhind

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Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design, Kazumasa Funabashi, Mizuki Sawata, Anna Nagai, Megumi Akimoto, Ryutaro Mashimo, Hidenari Takahara, Kenji Kizawa, Paul R. Thompson, Kenji Ite, Kenichi Kitanishi, and Masaki Unno

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Epigenomics of Post-testicular Sperm Maturation, Carolina Galan

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Stability of the cytosine methylome during post-testicular sperm maturation in mouse, Carolina Galan, Ryan W. Serra, Fengyun Sun, Vera D. Rinaldi, Colin C. Conine, and Oliver J. Rando

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Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit, Matthew D. Hall, James M. Anderson, Celia A. Schiffer, Anthony J. Conley, and Mindy I. Davis

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Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses, Wayne D. Harshbarger, Derrick Deming, Gordon J. Lockbaum, Nattapol Attatippaholkun, Maliwan Kamkaew, Shurong Hou, Mohan Somasundaran, Jennifer P. Wang, Robert W. Finberg, Quan Karen Zhu, Celia A. Schiffer, and Wayne A Marasco

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Enzymatic enhancing of triplet-triplet annihilation upconversion by breaking oxygen quenching for background-free biological sensing, Ling Huang, Timmy Le, Kai Huang, and Gang Han

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Long wavelength single photon like driven photolysis via triplet triplet annihilation, Ling Huang, Le Zeng, Yongzhi Chen, Nuo Yu, Lei Wang, Kai Huang, Yang Zhao, and Gang Han

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Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders, Benxia Hu, Hyejung Won, Won Mah, Royce B. Park, Bibi Kassim, Keeley Spiess, Alexey Kozlenkov, Cheynna A. Crowley, Sirisha Pochareddy, Yun Li, Stella Dracheva, Nenad Sestan, Schahram Akbarian, Daniel H. Geschwind, PsychENCODE Consortium, Eugenio Mattei, Michael J. Purcaro, Zhiping Weng, Jill E. Moore, Henry E. Pratt, Jack Huey, and Tyler M. Borrman

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A conserved folding nucleus sculpts the free energy landscape of bacterial and archaeal orthologs from a divergent TIM barrel family, Rohit Jain, Khaja Muneeruddin, Jeremy Anderson, Michael J. Harms, Scott A. Shaffer, and C. Robert Matthews

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CtBPs and IRF3 at the Intersection of Transcriptional Regulation by Macromolecular Complexes, Anne M. Jecrois

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Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy [preprint], Eun-Ik Koh, Megan K. Proulx, Kenan C. Murphy, Kadamba Papavinasasundaram, Charlotte Reames, Richard E. Baker, Roshanak Aslebagh, Scott A. Shaffer, and Christopher M. Sassetti

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SARS-CoV-2 Initiates Programmed Cell Death in Platelets, Milka Koupenova-Zamor, Heather A. Corkrey, Olga Vitseva, Kahraman Tanriverdi, Mohan Somasundaran, Ping Liu, Shaukat Soofi, Krishna M. Parsi, Alyssa Cousineau, Rene Maehr, Jennifer P. Wang, Jeffrey J. Rade, and Robert W. Finberg

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Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways, Carrie Kovalak, Scott Donovan, Alicia A. Bicknell, Mihir Metkar, and Melissa J. Moore

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Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning, Florian Leidner, Nese Kurt Yilmaz, and Celia A. Schiffer

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Citrullinated vimentin mediates development and progression of lung fibrosis, Fu Jun Li, Santanu Mondal, Paul R. Thompson, and Veena B. Antony

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Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode, Gordon J. Lockbaum, Mina Henes, Jeong Min. Lee, Jennifer Timm, Ellen A. Nalivaika, Paul R. Thompson, Nese Kurt Yilmaz, and Celia A. Schiffer

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Inhibiting HTLV-1 Protease: A Viable Antiviral Target, Gordon J. Lockbaum, Mina Henes, Nathaniel Talledge, Linah Rusere, Klajdi Kosovrasti, Ellen A. Nalivaika, Mohan Somasundaran, Akbar Ali, Louis M. Mansky, Nese Kurt Yilmaz, and Celia A. Schiffer

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Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188, Gordon J. Lockbaum, Archie C. Reyes, Jeong Min Lee, Ronak Tilvawala, Ellen A. Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Paul R. Thompson, and Celia A. Schiffer

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Insights into the Role of SARM1 in Pathological Neuron Death, Heather S. Loring

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A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration, Heather S. Loring, Victoria L. Czech, Janneke D. Icso, Lauren C. O'Connor, Sangram Parelkar, Alexandra B. Byrne, and Paul R. Thompson

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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines, Jeremy Luban, Caterina Strambio-De-Castilla, Yetao Wang, Allan Jacobson, and Stuart W. Peltz

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Interactions of APOBEC3s with DNA and RNA, Atanu Maiti, Shurong Hou, Celia A. Schiffer, and Hiroshi Matsuo

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Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond, Ashley N. Matthew, Florian Leidner, Gordon J. Lockbaum, Mina Henes, Jacqueto Zephyr, Shurong Hou, Nageswara Rao Desaboini, Jennifer Timm, Linah N. Rusere, Debra A. Ragland, Janet L. Paulsen, Kristina L. Prachanronarong, Djade I. Soumana, Ellen A. Nalivaika, Nese Kurt Yilmaz, Akbar Ali, and Celia A. Schiffer

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Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System [preprint], Michael P. Moazami, Julia M. Rembetsy-Brown, Feng Wang, Pranathi Meda Krishnamurthy, Alexandra Weiss, Miklos G. Marosfoi, Robert M. King, Mona Motwani, Heather L. Gray-Edwards, Katherine A. Fitzgerald, Robert H. Brown Jr., and Jonathan K. Watts

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Chemical biology of protein citrullination by the protein A arginine deiminases, Santanu Mondal and Paul R. Thompson

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Site-specific incorporation of citrulline into proteins in mammalian cells, Santanu Mondal, Shu Wang, Yunan Zheng, Sudeshna Sen, Abhishek Chatterjee, and Paul R. Thompson

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Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies [preprint], Frauke Muecksch, Shurong Hou, Celia A. Schiffer, Michel Nussenzweig, Pamela J. Bjorkman, Theodora Hatziioannou, and Paul Bieniasz

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Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations, Frauke Muecksch, Shurong Hou, Celia A. Schiffer, Michel C. Nussenzweig, Pamela J. Bjorkman, Theodora Hatziioannou, and Paul D. Bieniasz

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Distinguishing Signal From Noise in Immunopeptidome Studies of Limiting-Abundance Biological Samples: Peptides Presented by I-A(b) in C57BL/6 Mouse Thymus, Padma P. Nanaware, Mollie M. Jurewicz, Cristina C. Clement, Liying Lu, Laura Santambrogio, and Lawrence J. Stern

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Genetic and spatial organization of the unusual chromosomes of the dinoflagellate Symbiodinium microadriaticum, Ankita Nand, Ye Zhan, Octavio R. Salazar, Manuel Aranda, Christian R. Voolstra, and Job Dekker

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NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP), Jeffry C. Nichols, Celia A. Schiffer, and William E. Royer

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Genome information processing by the INO80 chromatin remodeler positions nucleosomes, Elisa Oberbeckmann, Nils Krietenstein, Vanessa Niebauer, Yingfei Wang, Kevin Schall, Manuela Moldt, Tobias Straub, Remo Rohs, Karl-Peter Hopfner, Philipp Korber, and Sebastian Eustermann

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Departing the coast of dystopia, Thoru Pederson

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Remembering and admiring the CDC, Thoru Pederson

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Biophysical basis of cellular multi-specificity encoded in a model molecular switch [preprint], Tina Perica, Christopher J. P. Mathy, Jiewei Xu, Gwendolyn M. Jang, Yang Zhang, Robyn Kaake, Noah Ollikainen, Hannes Braberg, Danielle L. Swaney, David G. Lambright, Mark J. S. Kelly, Nevan J. Krogan, and Tanja Kortemme

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Analysis of Emerging Variants in Structured Regions of the SARS-CoV-2 Genome, Sean P. Ryder, Brittany R. Morgan, Peren Coskun, Katianna Antkowiak, and Francesca Massi

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Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins [preprint], Stuti Sharma, Ruoyu Zhou, Li Wan, KangKang Song, Chen Xu, Yanyan Li, and Maofu Liao

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Lessons from a local effort to screen for SARS-CoV-2, Noah J. Silverstein and Jeremy Luban

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Innate lymphoid cells and disease tolerance in SARS-CoV-2 infection [preprint], Noah J. Silverstein, Yetao Wang, Zachary Manickas-Hill, Claudia C. Carbone, Ann Dauphin, MGH COVID-19 Collection & Processing Team, Jonathan Z. Li, Bruce D. Walker, Xu G. Yu, and Jeremy Luban

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Cell-type specific circadian bioluminescence rhythms recorded from Dbp reporter mice reveal circadian oscillator misalignment [preprint], Ciearra B. Smith, Vincent van der Vinne, Eleanor McCartney, Adam C. Stowie, Tanya L. Leise, Blanca Martin-Burgos, Penny C. C. Molyneux, Lauren A. Garbutt, Michael H. Brodsky, Alec J. Davidson, Mary E. Harrington, Robert Dallmann, and David R. Weaver

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Distinct allosteric mechanisms of first-generation MsbA inhibitors [preprint], François A. Thélot, Wenyi Zhang, KangKang Song, Chen Xu, Jing Huang, and Maofu Liao

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Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML, Zuzana Tothova, Anne-Laure Valton, Sergey V. Venev, Job Dekker, and Benjamin L. Ebert

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A cohesin traffic pattern genetically linked to gene regulation [preprint], Anne-Laure Valton, Sergey V. Venev, Barbara Mair, Eraj Khokhar, Amy H. Y. Tong, Matej Usaj, Katherine S. K. Chan, Athma A. Pai, Jason Moffat, and Job Dekker

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Deficient spermiogenesis in mice lacking Rlim, Feng Wang, Maria Gracia Gervasi, Ana Boskovic, Fengyun Sun, Vera D. Rinaldi, Jun Yu, Mary C. Wallingford, Darya A. Tourzani, Jesse Mager, Lihua Julie Zhu, Oliver J. Rando, Pablo E. Visconti, Lara Strittmatter, and Ingolf Bach

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Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication, Weitao Wang, Kyle N. Klein, Karel Proesmans, Hongbo Yang, Claire Marchal, Xiaopeng Zhu, Tyler M. Borrman, Alex Hastie, Zhiping Weng, John Bechhoefer, Chun-Long Chen, David M. Gilbert, and Nicholas R. Rhind

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Clarification of human blood ILC subtype interrelatedness and discovery of amphiregulin production by human NK cells shed light on HIV-1 pathogenesis [preprint], Yetao Wang, Lawrence M. Lifshitz, Noah J. Silverstein, Esther Mintzer, Kevin Luk, Pamela St. Louis, Michael A. Brehm, Scot A. Wolfe, Steven G. Deeks, and Jeremy Luban

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FastTomo: A SerialEM Script for Collecting Electron Tomography Data [preprint], Albert Xu and Chen Xu

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Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice [preprint], Chunxing Yang, Tao Qiao, Jia Yu, Hongyan Wang, Yansu Guo, Johnny Salameh, Jake P. Metterville, Sepideh Parsi, Robert H. Brown Jr., Huaibin Cai, and Zuoshang Xu

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Introduction: Drug Resistance, Nese Kurt Yilmaz and Celia A. Schiffer

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Robust Drug Design Strategies and Discovery Targeting Viral Proteases, Jacqueto Zephyr

Publications from 2020

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Deconstructing bioluminescence: from molecular detail to in vivo imaging., Spencer T. Adams Jr.

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Systematic evaluation of chromosome conformation capture assays [preprint], Betul Akgol-Oksuz, Liyan Yang, Sergey V. Venev, Nils Krietenstein, Krishna M. Parsi, Hakan Ozadam, Marlies E. Oomen, Ankita Nand, Hui Mao, Ryan M.J. Genga, Rene Maehr, Oliver J. Rando, Johan H. Gibcus, and Job Dekker

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In-Vitro Sorbent-Mediated Removal of Edoxaban from Human Plasma and Albumin Solution, Alexandra A. Angheloiu, Yanglan Tan, Cristian Ruse, Scott A. Shaffer, and George O. Angheloiu

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mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding, Chen Bao, Sarah Loerch, Clarence Ling, Andrei A. Korostelev, Nikolaus Grigorieff, and Dmitri N. Ermolenko

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mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding [preprint], Chen Bao, Sarah Loerch, Clarence Ling, Andrei A. Korostelev, Nikolaus Grigorieff, and Dmitri N. Ermolenko

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Linearized Siderophore Products Secreted via MacAB Efflux Pump Protect Salmonella enterica Serovar Typhimurium from Oxidative Stress, L M. Bogomolnaya, Ronak Tilvawala, J. R. Elfenbein, J. D. Cirillo, and H. L. Andrews-Polymenis

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HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation, Laure Bridoux, Peyman Zarrineh, Joshua Mallen, Mike Phuycharoen, Victor Latorre, Frank Ladam, Marta Losa, Syed Murtuza Baker, Charles G. Sagerstrom, Kimberly A. Mace, Magnus Rattray, and Nicoletta Bobola

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Clustering of strong replicators associated with active promoters is sufficient to establish an early-replicating domain, Caroline Brossas, Anne-Laure Valton, Sergey V. Venev, Sabarinadh Chilaka, Antonin Counillon, Marc Laurent, Coralie Goncalves, Benedicte Duriez, Franck Picard, Job Dekker, and Marie-Noelle Prioleau

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Acidic pH Triggers Lipid Mixing Mediated by Lassa Virus GP, Uriel Bulow, Ramesh Govindan, and James B. Munro

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Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes, Erica P. Cai, Yuki Ishikawa, Wei Zhang, Nayara C. Leite, Jian Li, Shurong Hou, Badr Kiaf, Jennifer Hollister-Lock, Nese Kurt Yilmaz, Celia A. Schiffer, Douglas A. Melton, Stephan Kissler, and Peng Yi

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ArfB can displace mRNA to rescue stalled ribosomes, Christine E. Carbone, Gabriel Demo, Rohini Madireddy, Egor Svidritskiy, and Andrei A. Korostelev

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Linker histone H1.8 inhibits chromatin-binding of condensins and DNA topoisomerase II to tune chromosome compaction and individualization [preprint], Pavan Choppakatla, Bastiaan Dekker, Erin E. Cutts, Alessandro Vannini, Job Dekker, and Hironori Funabiki

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Understanding the Production and Stability of Mouse PIWI-Interacting RNAs, Cansu Colpan

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Flexibility and constraint in preimplantation gene regulation in mouse [preprint], Colin C. Conine, Marina Krykbaeva, Lina Song, Robert C. Brewster, Nir Friedman, and Oliver J. Rando

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Investigating Evolutionary Innovation in Yeast Heat Shock Protein 90, Pamela Cote-Hammarlof

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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding, Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, and James B. Munro

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Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation [preprint], Gabriel Demo, Anna B. Loveland, Egor Svidritskiy, Howard B. Gamper, Ya-Ming Hou, and Andrei A. Korostelev

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SPEN integrates transcriptional and epigenetic control of X-inactivation, Francois Dossin, Ines Pinheiro, Jan J. Zylicz, Julia Roensch, Samuel Collombet, Agnes Le Saux, Tomasz Chelmicki, Mikael Attia, Varun Kapoor, Ye Zhan, Florent Dingli, Damarys Loew, Thomas Mercher, Job Dekker, and Edith Heard (Nature, 2020-02-05)

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Competition for MCM Loading at Origins Establishes Replication Timing Patterns [preprint], Livio Dukaj and Nicholas R. Rhind

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Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription, Ying Feng, Yao Wang, Xiangnan Wang, Xiaohui He, Chen Yang, Ardalan Naseri, Thoru Pederson, Jing Zheng, Shaojie Zhang, Xiao Xiao, Wei Xie, and Hanhui Ma

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Simultaneous Epigenetic Perturbation and Genome Imaging Reveal Distinct Roles of H3K9me3 in Chromatin Architecture and Transcription [preprint], Ying Feng, Yao Wang, Xiangnan Wang, Xiaohui He, Chen Yang, Ardalan Naseri, Thoru Pederson, Jing Zheng, Shaojie Zhang, Xiao Xiao, Wei Xie, and Hanhui Ma

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Large domains of heterochromatin direct the formation of short mitotic chromosome loops, Maximilian H. Fitz-James, Pin Tong, Alison L. Pidoux, Hakan Ozadam, Liyan Yang, Sharon A. White, Job Dekker, and Robin C. Allshire

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Comprehensive fitness maps of Hsp90 show widespread environmental dependence, Julia M. Flynn, Ammeret Rossouw, Pamela A. Cote-Hammarlof, Ines Fragata, David Mavor, Carl Hollins III, Claudia Bank, and Daniel N. Bolon

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Early life lessons: The lasting effects of germline epigenetic information on organismal development, Carolina Galan, Marina Krykbaeva, and Oliver J. Rando

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Cytosine methylation dynamics during post-testicular sperm maturation in mammals [preprint], Carolina Galan, Ryan W. Serra, Fengyun Sun, Vera Rinaldi, Colin C. Conine, and Oliver J. Rando

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Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism [preprint], Christl Gaubitz, Xingchen Liu, Joseph Magrino, Nicholas P. Stone, Jacob Landeck, Mark Hedglin, and Brian A. Kelch

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Transcriptional Silencers in Drosophila Serve a Dual Role as Transcriptional Enhancers in Alternate Cellular Contexts, Stephen S. Gisselbrecht, Alexandre Palagi, Jesse V. Kurland, Julia M. Rogers, Hakan Ozadam, Ye Zhan, Job Dekker, and Martha L. Bulyk (Molecular cell, 2020-01-16)

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A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry, Janelle A. Hayes, Brendan J. Hilbert, Christl Gaubitz, Nicholas P. Stone, and Brian A. Kelch

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Mechanisms and Functions of Chromosome Compartmentalization, Erica M. Hildebrand and Job Dekker

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Structural Mechanism of Substrate Specificity In Human Cytidine Deaminase Family APOBEC3s, Shurong Hou

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Highly Effective Near-Infrared Activating Triplet-Triplet Annihilation Upconversion for Photoredox Catalysis, Ling Huang, Wenting Wu, Yang Li, Kai Huang, Le Zeng, Wenhai Lin, and Gang Han

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Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly, Shijie Huang, Nikolay A. Aleksashin, Anna B. Loveland, Dorota Klepacki, Kaspar Reier, Amira Kefi, Teresa Szal, Jaanus Remme, Luc Jaeger, Nora Vazquez-Laslop, Andrei A. Korostelev, and Alexander S. Mankin

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Succination inactivates gasdermin D and blocks pyroptosis, Fiachra Humphries, Liraz Shmuel-Galia, Natalia Ketelut-Carneiro, Ruth Wilson, Zhaozhao Jiang, Farnaz Khalighinejad, Khaja Muneeruddin, Scott A. Shaffer, Carolina Ionete, Paul R. Thompson, and Katherine A. Fitzgerald

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The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation [preprint], Anthony N. Imbalzano, Hanna Witwicka, and Tapan Sharma

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CryoEM Structure of CtBP2 Confirms Tetrameric Architecture [preprint], Anne M. Jecrois, M. Michael Dcona, Xiaovan Deng, Dipankar Bandyopadhyay, Steven R. Grossman, Celia A. Schiffer, and William E. Royer

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Cryo-EM Structure of CtBP2 Confirms Tetrameric Architecture, Anne M. Jecrois, M. Michael Dcona, Xiaoyan Deng, Dipankar Bandyopadhyay, Steven R. Grossman, Celia A. Schiffer, and William E. Royer Jr.

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Thermus thermophilus Argonaute Functions in the Completion of DNA Replication, Samson M. Jolly, Ildar Gainetdinov, , Han Zhang, Lara Strittmatter, Shannon M. Bailey, Gregory M. Hendricks, Avantika Dhabaria, Beatrix Ueberheide, and Phillip D. Zamore

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Histone exchange is associated with activator function at transcribed promoters and with repression at histone loci, Sari Kassem, Paolo Ferrari, Amanda L. Hughes, Julien Soudet, Oliver J. Rando, and Michel Strubin

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STRIDE-a fluorescence method for direct, specific in situ detection of individual single- or double-strand DNA breaks in fixed cells, Magdalena M. Kordon, Miroslaw Zarebski, Kamil Solarczyk, Hanhui Ma, Thoru Pederson, and Jurek W. Dobrucki

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Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved AS-NMD pathways, Carrie A. Kovalak

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Ultrastructural Details of Mammalian Chromosome Architecture, Nils Krietenstein, Sameer Abraham, Sergey V. Venev, Nezar Abdennur, Johan H. Gibcus, Tsung-Han S. Hsieh, Krishna M. Parsi, Liyan Yang, Rene Maehr, Leonid A. Mirny, Job Dekker, and Oliver J. Rando (Molecular cell, 2020-03-14)

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Deciphering complex mechanisms of resistance and loss of potency through coupled molecular dynamics and machine learning [preprint], Florian Leidner, Nese Kurt Yilmaz, and Celia A. Schiffer