This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Biochemistry and Molecular Pharmacology.

Follow


Publications from 2020

PDF

Identification and Characterization of the Lactating Mouse Mammary Gland Citrullinome, Guangyuan Li, Coleman H. Young, Bryce Snow, Amanda O. Christensen, M. Kristen Demoruelle, Venkatesh V. Nemmara, Paul R. Thompson, Heather M. Rothfuss, and Brian D. Cherrington

PDF

Molecular Mechanisms of Resistance and Structure-Based Drug Design in Homodimeric Viral Proteases, Gordon J. Lockbaum

Link

Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures, Gordon J. Lockbaum, Florian Leidner, William E. Royer, Nese Kurt Yilmaz, and Celia A. Schiffer

PDF

The History of Farm Foxes Undermines the Animal Domestication Syndrome, Kathryn A. Lord, Greger Larson, Raymond P. Coppinger, and Elinor K. Karlsson

Link

Initial Kinetic Characterization of Sterile Alpha and Toll/Interleukin Receptor Motif-Containing Protein 1, Heather S. Loring, Janneke D. Icso, Venkatesh V. Nemmara, and Paul R. Thompson

Link

Identification of the first noncompetitive SARM1 inhibitors, Heather S. Loring, Sangram Parelkar, Santanu Mondal, and Paul R. Thompson

Link

Emergence of SARM1 as a Potential Therapeutic Target for Wallerian-type Diseases, Heather S. Loring and Paul R. Thompson

PDF

Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM [preprint], Anna B. Loveland, Egor Svidritskiy, Denis Susorov, Soojin Lee, Alexander Park, Gabriel Demo, Fen-Biao Gao, and Andrei A. Korostelev

Link

Crystal Structure of a Soluble APOBEC3G Variant Suggests ssDNA to Bind in a Channel that Extends between the Two Domains, Atanu Maiti, Wazo Myint, Krista A. Delviks-Frankenberry, Shurong Hou, Tapan Kanai, Vanivilasini Balachandran, Christina Sierra Rodriguez, Rashmi Tripathi, Nese Kurt Yilmaz, Vinay K. Pathak, Celia A. Schiffer, and Hiroshi Matsuo

PDF

Methods for detecting PER2::LUCIFERASE bioluminescence rhythms in freely moving mice [preprint], B. Martin-Burgos, W. Wang, I. William, S. Tir, I. Mohammad, R. Javed, Smith College, Y. Cui, Ciearra B. Smith, V. van der Vinne, P.C. Molyneux, Stephen C. Miller, David R. Weaver, T.L. Leise, and M.E. Harrington

PDF

Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors, Ashley N. Matthew, Jacqueto Zephyr, Nageswara Rao Desaboini, Mina Henes, Wasih Kamran, Klajdi Kosovrasti, Adam Hedger, Gordon J. Lockbaum, Jennifer Timm, Akbar Ali, Nese Kurt Yilmaz, and Celia A. Schiffer

Link

IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity [preprint], Ejemel Monir, Qi Li, Shurong Hou, Zachary Schiller, Aaron Wallace, Alla Amcheslavsky, Nese Kurt Yilmaz, Jacqueline R. Toomey, Ryan Schneider, Lisa Cavacini, Mark S. Klempner, Celia A. Schiffer, and Yan Wang

PDF

A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction, Ejemel Monir, Qi Li, Shurong Hou, Zachary Schiller, Aaron Wallace, Alla Amcheslavsky, Nese Kurt Yilmaz, Jacqueline R. Toomey, Ryan Schneider, Anudeep S. Ramchetty, Chandrashekar Ganesa, Lisa Cavacini, Mark S. Klempner, Celia A. Schiffer, and Yan Wang

PDF

Chromosome-scale assembly of the coral endosymbiont Symbiodinium microadriaticum genome provides insight into the unique biology of dinoflagellate chromosomes [preprint], Ankita Nand, Ye Zhan, Octavio R. Salazar, Manuel Aranda, Christian R. Voolstra, and Job Dekker

PDF

Genome information processing by the INO80 chromatin remodeler positions nucleosomes [preprint], Elisa Oberbeckmann, Nils Krietenstein, Vanessa Niebauer, Yingfei Wang, Kevin Schall, Manuela Moldt, Tobias Straub, Remo Rohs, Karl-Peter Hopfner, Philipp Korber, and Sebastian Eustermann

PDF

Detecting chromatin interactions along and between sister chromatids with SisterC [preprint], Marlies E. Oomen, Adam K. Hedger, Jonathan K. Watts, and Job Dekker

Link

Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans, Deniz M. Ozata, Tianxiong Yu, Haiwei Mou, Ildar Gainetdinov, Cansu Colpan, Katharine Cecchini, Yasin Kaymaz, Pei-Hsuan Wu, Kaili Fan, Alper Kucukural, Zhiping Weng, and Phillip D. Zamore

PDF

CK2-Dependent Phosphorylation of the Brg1 Chromatin Remodeling Enzyme Occurs during Mitosis, Teresita Padilla-Benavides, Dominic T. Haokip, Yeonsoo Yoon, Pablo Reyes-Gutierrez, Jaime A. Rivera, and Anthony N. Imbalzano

PDF

Regulation of the Mammalian SWI/SNF Family of Chromatin Remodeling Enzymes by Phosphorylation during Myogenesis, Teresita Padilla-Benavides, Pablo Reyes-Gutierrez, and Anthony N. Imbalzano

PDF

Viral Packaging ATPases Utilize a Glutamate Switch to Couple ATPase Activity and DNA Translocation [preprint], Joshua Pajak, Rockney Atz, Brendan J. Hilbert, Marc C. Morais, Brian A. Kelch, and Paul Jardine

PDF

Atomistic Mechanism of Force Generation, Translocation, and Coordination in a Viral Genome Packaging Motor [preprint], Joshua Pajak, Erik Dill, Mark A. White, Brian A. Kelch, Paul Jardine, Gaurav Arya, and Marc C. Morais

PDF

PFN1 phosphorylation marks protein aggregation and white matter pathology in ALS, Sepideh Parsi, Tao Qiao, Lyle Wilfred Ostrow, Marco B. Rust, and Zuoshang Xu

Link

Coronavirus conversations, in a time of logarithm, Thoru Pederson

Link

Publishing coronavirology: Peering into peer(less?) review, Thoru Pederson

Link

The 50th anniversary of reverse transcriptase-and its ironic legacy in the time of coronavirus, Thoru Pederson

Link

The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility, Pei-Hsuan Wu, Yu Fu, Katharine Cecchini, Deniz M. Ozata, Amena Arif, Tianxiong Yu, Cansu Colpan, Ildar Gainetdinov, Zhiping Weng, and Phillip D. Zamore

PDF

An atlas of cell types in the mammalian epididymis and vas deferens [preprint], Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando

PDF

An atlas of cell types in the mouse epididymis and vas deferens, Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando

PDF

Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-Tetrahydrofuran in a Pseudo-Symmetric Dipeptide Isostere, Linah Rusere, Gordon J. Lockbaum, Mina Henes, Sook-Kyung Lee, Ean Spielvogel, Desaboini Nageswara Rao, Klajdi Kosovrasti, Ellen A. Nalivaika, Ronald Swanstrom, Nese Kurt Yilmaz, Celia A. Schiffer, and Akbar Ali

Link

Analysis of Rapidly Emerging Variants in Structured Regions of the SARS-CoV-2 Genome [preprint], Sean P. Ryder

PDF

Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice, Fernanda M. C. Sodré, Samal Bissenova, Ylke Bruggeman, Ronak Tilvawala, Dana P. Cook, Claire Berthault, Santanu Mondal, Aïsha Callebaut, Sylvaine You, Raphael Scharfmann, Roberto Mallone, Paul R. Thompson, Chantal Mathieu, Mijke Buitinga, and Lut Overbergh

Link

Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors, Yu H. Sun, Jiang Zhu, Li Huitong Xie, Ziwei Li, Rajyalakshmi Meduri, Xiaopeng Zhu, Chi Song, Chen Chen, Emiliano P. Ricci, Zhiping Weng, and Xin Zhiguo Li

PDF

Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis, Yuzi Tian, Santanu Mondal, Paul R. Thompson, and Yongqing Li

Link

Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir, Jennifer Timm, Klajdi Kosovrasti, Mina Henes, Florian Leidner, Shurong Hou, Akbar Ali, Nese Kurt Yilmaz, and Celia A. Schiffer

PDF

Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines, Pinar Uysal-Onganer, Amy MacLatchy, Rayan Mahmoud, Igor Kraev, Paul R. Thompson, Jameel M. Inal, and Sigrun Lange

Link

Performance of ZDOCK and IRAD in CAPRI rounds 39-45, Thom Vreven, Sweta Vangaveti, Tyler M. Borrman, Jennifer C. Gaines, and Zhiping Weng

PDF

Genome-Wide Mapping of Human DNA Replication by Optical Replication Mapping Supports a Stochastic Model of Eukaryotic Replication Timing [preprint], Weitao Wang, Kyle Klein, Karel Proesmans, Northwestern University, Claire Marchal, Xiaopeng Zhu, Tyler M. Borrman, Alex Hastie, Zhiping Weng, Simon Fraser University, Paris Sciences et Lettres University, Florida State University, and Nicholas R. Rhind

Link

HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells, Yetao Wang, Lawrence M. Lifshitz, Kyle Gellatly, Sean M. McCauley, Pranitha Vangala, Kyusik Kim, Alan G. Derr, Smita Jaiswal, Alper Kucukural, Patrick McDonel, Thomas C. Greenough, JeanMarie Houghton, Manuel Garber, and Jeremy Luban

Link

Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock, Zhenyu Wu, Qiufang Deng, Baihong Pan, Hasan B. Alam, Yuzi Tian, Umar F. Bhatti, Baoling Liu, Santanu Mondal, Paul R. Thompson, and Yongqing Li

Link

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant, Leonid Yurkovetskiy, Thomas Nyalile, Yetao Wang, William E. Diehl, Ann Dauphin, Claudia Carbone, Kristen Veinotte, Shawn B Egri, James B. Munro, Pardis C. Sabeti, Christos A. Kyratsous, Natalya V. Dudkina, Kuang Shen, and Jeremy Luban

PDF

SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain [preprint], Leonid Yurkovetskiy, Thomas Nyalile, Yetao Wang, William E. Diehl, Ann Dauphin, Claudia Carbone, Kristen Veinotte, Shawn B. Egri, Pardis C. Sabeti, Christos Kyratsous, James B. Munro, Kuang Shen, and Jeremy Luban

PDF

PAD2 Dysregulation and Abnormal Protein Citrullination in ALS Disease Models, Issa Yusuf, Tao Qiao, Ronak Tilvawala, Paul R. Thompson, and Zuoshang Xu

PDF

rad21 Is Involved in Corneal Stroma Development by Regulating Neural Crest Migration, Bi Ning Zhang, Yu Liu, Qichen Yang, Pui Ying Leung, Chengdong Wang, Thomas Chi Wong Bun, Clement C. Tham, Sun On Chan, Chi Pui Pang, Li Jia Chen, Job Dekker, Hui Zhao, and Wai Kit Chu

Publications from 2019

Link

A chromosome folding intermediate at the condensin-to-cohesin transition during telophase, Kristin Abramo, Anne-Laure Valton, Sergey V. Venev, Hakan Ozadam, A. Nicole Fox, and Job Dekker (Nature cell biology, 2019-11-01)

PDF

A chromosome folding intermediate at the condensin-to-cohesin transition during telophase [preprint], Kristin Abramo, Anne-Laure Valton, Sergey V. Venev, Hakan Ozadam, A. Nicole Fox, and Job Dekker

PDF

Highly structured homolog pairing reflects functional organization of the Drosophila genome, Jumana AlHaj Abed, Jelena Erceg, Anton Goloborodko, Son C. Nguyen, Ruth B. McCole, Wren Saylor, Geoffrey Fudenberg, Bryan R. Lajoie, Job Dekker, Leonid A. Mirny, and C-Ting Wu (Nature communications, 2019-10-03)

Link

Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS, Desiree Baron, Tyler Matheny, Yen-Chen Lin, John D. Leszyk, Kevin P. Kenna, Katherine V. Gall, David P. Santos, Maeve Tischbein, Salome Funes, Lawrence J. Hayward, Evangelos Kiskinis, John E. Landers, Roy Parker, Scott A. Shaffer, and Daryl Bosco

Link

Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses, Aniuska Becerra Artiles, John Cruz, John D. Leszyk, John Sidney, Alessandro Sette, Scott A. Shaffer, and Lawrence J. Stern

Link

Aquatic adaptation and depleted diversity: a deep dive into the genomes of the sea otter and giant otter, Annabel C. Beichman, Klaus-Peter Koepfli, Gang Li, William Murphy, Pasha Dobrynin, Sergei Kilver, M. Tim Tinker, Michael J. Murray, Jeremy Johnson, Kerstin Lindblad-Toh, Elinor K. Karlsson, Kirk E. Lohmueller, and Robert K. Wayne

PDF

Mechanistic Basis for Control of Early Embryonic Development by a 5’ tRNA Fragment, Xin Y. Bing

Link

Constrained mutational sampling of amino acids in HIV-1 protease evolution, Jeffrey I. Boucher, Troy W. Whitfield, Ann Dauphin, Gily S. Nachum, Carl Hollins III, Konstantin B. Zeldovich, Ronald Swanstrom, Celia A. Schiffer, Jeremy Luban, and Daniel N. Bolon

PDF

HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation [preprint], Laure Bridoux, Peyman Zarrineh, Joshua Mallen, Mike Phuycharoen, Victor Latorre, Frank Ladam, Marta Losa, Charles G. Sagerstrom, Kimberley A. Mace, Magnus Rattray, and Nicoletta Bobola

PDF

Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals, Nicholas R. Casewell, Elinor K. Karlsson, Daniel Petras, Daren C. Card, Vivek Suranse, Alexis M. Mychajliw, David Richards, Ivan Koludarov, Laura-Oana Albulescu, Julien Slagboom, Benjamin-Florian Hempel, Neville M. Ngum, Rosalind J. Kennerley, Jorge L. Brocca, and Gareth Whiteley

Link

Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in Reconstructed Human Epidermis, Laura Cau, Hidenari Takahara, Paul R. Thompson, Guy Serre, Marie-Claire Mechin, and Michel Simon

PDF

The Plasticity and Variation in Gene Expression during Development in C. elegans, Io Long Chan

PDF

Exploring the Complex Folding Free Energy Landscapes of a Series of β-rich Proteins, Noah R. Cohen

PDF

Nonnative structure in a peptide model of the unfolded state of SOD1: Implications for ALS-linked aggregation, Noah R. Cohen, Jill A. Zitzewitz, Osman Bilsel, and C. Robert Matthews

Link

MicroRNAs Absent in Caput Sperm Are Required for Normal Embryonic Development, Colin C. Conine, Fengyun Sun, Lina Song, Jaime A. Rivera-Perez, and Oliver J. Rando

PDF

The adaptive potential of the M-domain of yeast Hsp90 [preprint], Pamela A. Cote-Hammarlof, Inês Fragata, Julia M. Flynn, Konstantin B. Zeldovich, Claudia Bank, and Daniel N. Bolon

PDF

Control of cellular responses to mechanical cues through YAP/TAZ regulation, Ishani Dasgupta and Dannel McCollum

PDF

Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes, Sanchaita Das, Andrew W. Malaby, Agata Nawrotek, Wenhua Zhang, Mahel Zeghouf, Sarah Maslen, Mark Skehel, Srinivas Chakravarthy, Thomas C. Irving, Osman Bilsel, Jacqueline Cherfils, and David G. Lambright

Link

Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonance imaging and spectroscopy study, Kristina M. Deligiannidis, Christina L. Fales, Aimee Kroll-Desrosiers, Scott A. Shaffer, Vanessa Villamarin, Yanglan Tan, Janet E. Hall, Blaise B. Frederick, Elif M. Sikoglu, Richard A. Edden, Anthony J. Rothschild, and Constance M. Moore

PDF

Identification of the hyaluronic acid pathway as a therapeutic target for facioscapulohumeral muscular dystrophy, Alec M. DeSimone; John D. Leszyk; Kathryn Wagner; and Charles P. Emerson, Jr.

PDF

Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment, Vishnu Dileep, Rachel Patton McCord, Job Dekker, and David M. Gilbert

Link

TRAPPing a Rab GTPase by the Tail, Jianjun Duan and David G. Lambright

PDF

Modulating MCM Levels Causes Differential Loading at Origins of Replication and Changes Replication Timing, Livio Dukaj

PDF

The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos, Jelena Erceg, Jumana AlHaj Abed, Anton Goloborodko, Bryan R. Lajoie, Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Ruth B. McCole, Son C. Nguyen, Wren Saylor, Eric F. Joyce, T. Niroshini Senaratne, Mohammed A. Hannan, Guy Nir, Job Dekker, Leonid A. Mirny, and C-Ting Wu (Nature communications, 2019-10-03)

Link

Heterochromatin drives compartmentalization of inverted and conventional nuclei, Martin Falk, Yana Feodorova, Natalia Naumova, Maxim Imakaev, Bryan R. Lajoie, Heinrich Leonhardt, Boris Joffe, Job Dekker, Geoffrey Fudenberg, Irina Solovei, and Leonid A. Mirny (Nature, 2019-06-05)

PDF

Multimodal quantitative imaging of brain cancer in cultured cells, Xin Feng, Alona Muzikansky, Alonzo H. Ross, Michael R. Hamblin, Peter R. Jermain, and Anna N. Yaroslavsky

Link

Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization, Elizabeth H. Finn, Gianluca Pegoraro, Hugo B. Brandao, Anne-Laure Valton, Marlies E. Oomen, Job Dekker, Leonid Mirny, and Tom Misteli (Cell, 2019-03-07)

PDF

Investigating the influence of environment on the evolution of Hsp90 using comprehensive fitness maps [preprint], Julia M. Flynn, Ammeret Rossouw, Pamela A. Cote-Hammarlof, Ines Fragata, David Mavor, Carl Hollins III, Claudia Bank, and Daniel N. Bolon

Link

Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer, A. J. Fritz, Jeffrey A. Nickerson, Anthony N. Imbalzano, and Gary S. Stein

PDF

The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome, Michal R. Gdula, Tatyana B. Nesterova, Greta Pintacuda, Jonathan Godwin, Ye Zhan, Hakan Ozadam, Michael McClellan, Daniella Moralli, Felix Krueger, Catherine M. Green, Wolf Reik, Skirmantas Kriaucionis, Edith Heard, Job Dekker, and Neil Brockdorff

Link

The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria, Daniel Tianfang Ge, Wei Wang, Cindy Tipping, Ildar Gainetdinov, Zhiping Weng, and Phillip D. Zamore

Link

Epigenetic-genetic chromatin footprinting identifies novel and subject-specific genes active in prefrontal cortex neurons, Fedor E. Gusev, Anastasia P. Grigorenko, Elena Filippova, Zhiping Weng, Schahram Akbarian, and Evgeny I. Rogaev

PDF

Transfer RNA Genes Affect Chromosome Structure and Function via Local Effects, Omar Hamdani, Tsung-Han S. Hsieh, Oliver J. Rando, and Rohinton T. Kamakaka

PDF

Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition, Reka A. Haraszti, Rachael Miller, Michelle L. Dubuke, Andrew H. Coles, Marie C. Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John D. Leszyk, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Rachel Wollacott, Yan Wang, Scott A. Shaffer, Neil Aronin, and Anastasia Khvorova

PDF

The Mechanism and Regulation of Bacteriophage DNA Packaging Motors, Janelle A. Hayes

PDF

A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry [preprint], Janelle A. Hayes, Brendan J. Hilbert, Christl Gaubitz, Nicholas P. Stone, and Brian A. Kelch

Link

Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance, Mina Henes, Klajdi Kosovrasti, Gordon J. Lockbaum, Florian Leidner, Gily S. Nachum, Ellen A. Nalivaika, Daniel N. Bolon, Nese Kurt Yilmaz, Celia A. Schiffer, and Troy W. Whitfield

Link

Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance, Mina Henes, Gordon J. Lockbaum, Klajdi Kosovrasti, Florian Leidner, Gily S. Nachum, Ellen A. Nalivaika, Sook-Kyung Lee, Ean Spielvogel, Shuntai Zhou, Ronald Swanstrom, Daniel N. Bolon, Nese Kurt Yilmaz, and Celia A. Schiffer

Link

RUNX1-dependent mechanisms in biological control and dysregulation in cancer, Deli Hong, Andrew J. Fritz, Jonathan A. Gordon, Coralee E. Tye, Joseph R. Boyd, Kirsten M. Tracy, Seth E. Frietze, Frances E. Carr, Jeffrey A. Nickerson, Andre J. Van Wijnen, Anthony N. Imbalzano, Sayyed K. Zaidi, Jane B. Lian, Janet L. Stein, and Gary S. Stein

Link

NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations, Rieko Ishima, Nese Kurt Yilmaz, and Celia A. Schiffer

Link

Precise therapeutic gene correction by a simple nuclease-induced double-stranded break, Sukanya Iyer, Sneha Suresh, Dongsheng Guo, Katelyn Daman, Jennifer C. J. Chen, Pengpeng Liu, Marina Zieger, Kevin Luk, Benjamin P. Roscoe, Christian Mueller, Oliver D. King, Charles P. Emerson Jr., and Scot A. Wolfe

PDF

A DNA-guided Argonaute Protein Functions in DNA Replication in Thermus thermophilus [preprint], Samson M. Jolly, Ildar Gainetdinov, , Han Zhang, Lara Strittmatter, Gregory M. Hendricks, Avantika Dhabaria, Beatrix Ueberheide, and Phillip D. Zamore

PDF

A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness, Utsav Joshi, Lawrence J. Stern, and Laila Abdullah

PDF

Leptin induces cell migration and invasion in a FAK-Src- dependent manner in breast cancer cells, Juan Carlos Juarez-Cruz, Miriam Daniela. Zuniga-Eulogio, Monserrat Olea-Flores, Eduardo Castaneda-Saucedo, Miguel Angel. Mendoza-Catalan, Carlos Ortuno-Pineda, Ma Elena. Moreno-Godinez, Socrates Villegas-Comonfort, Teresita Padilla-Benavides, and Napoleon Navarro-Tito

PDF

Functional Analysis of DNMT3A DNA Methyltransferase Mutations Reported in Patients with Acute Myeloid Leukemia, Daria A. Khrabrova, Andrei G. Loiko, Anastasia A. Tolkacheva, Natalia A. Cherepanova, Maria I. Zvereva, Olga V. Kirsanova, and Elizaveta S. Gromova

Link

Cyclophilin A protects HIV-1 from restriction by human TRIM5alpha, Kyusik Kim, Ann Dauphin, Sevnur Komurlu, Sean M. McCauley, Leonid Yurkovetskiy, Claudia Carbone, William E. Diehl, Caterina Strambio-De-Castilla, Edward M. Campbell, and Jeremy Luban

PDF

Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing, Elsenoor Klaver, Peng Zhao, Melanie May, Heather Flanagan-Steet, Hudson H. Freeze, Reid Gilmore, Lance Wells, Joseph Contessa, and Richard Steet

PDF

Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved AS-NMD pathways [preprint], Carrie Kovalak, Mihir Metkar, and Melissa J. Moore

Link

Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression, Barry Kriegsman, Pranitha Vangala, Benjamin J. Chen, Paul Meraner, Abraham L. Brass, Manuel Garber, and Kenneth L. Rock

PDF

DEBrowser: interactive differential expression analysis and visualization tool for count data, Alper Kucukural, Onur Yukselen, Deniz M. Ozata, Melissa J. Moore, and Manuel Garber

PDF

Ste5 Membrane Localization Allows MAPK Pathway Signaling in trans Between Kinases on Separate Scaffold Molecules [preprint], Rachel E. Lamson, Matthew J. Winters, and Peter M. Pryciak

Link

Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints, Florian Leidner, Nese Kurt Yilmaz, and Celia A. Schiffer

Link

Blind prediction of homo- and hetero-protein complexes: The CASP13-CAPRI experiment, Marc F. Lensink, Thom Vreven, Sweta Vangaveti, Tyler M. Borrman, Zhiping Weng, and Shoshana J. Wodak

PDF

Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells, Fujun Li, Lixia Miao, Teng Xue, Hao Qin, Santanu Mondal, Paul R. Thompson, Scott A. Coonrod, Xiaoqiu Liu, and Xuesen Zhang

Link

Nordic OCD and Related Disorders Consortium: Rationale, design, and methods, David Mataix-Cols, Bjarne Hansen, Manuel Mattheisen, Elinor K. Karlsson, Anjene M. Addington, Julia Boberg, Diana R. Djurfeldt, Matthew Halvorsen, Paul Lichtenstein, Stian Solem, Kerstin Lindblad-Toh, Jan Haavik, Gerd Kvale, Christian Ruck, and James J. Crowley

Link

Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae, Yuqian Ma, Jin Bao, Yuanwei Zhang, Zhan Jun Li, Xiangyu Zhou, Changlin Wan, Ling Huang, Yang Zhao, Gang Han, and Tian Xue

Link

Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma, Kate Megquier, Elinor K. Karlsson, and Kerstin Lindblad-Toh