Title

The role of protein-solvent interactions in protein unfolding

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Publication Date

1996-08-01

Document Type

Article

Subjects

Computer Simulation; Models, Molecular; Protein Denaturation; *Protein Folding; Proteins; Solvents; Urea; Water

Disciplines

Biochemistry, Biophysics, and Structural Biology | Pharmacology, Toxicology and Environmental Health

Abstract

Protein unfolding occurs when the balance of forces between the protein's interaction with itself and the protein's interaction with its environment is disrupted. The disruption of this balance of forces may be as simple as a perturbance of the normal water structure around the protein. A decrease in the normal water-water interaction will result in an increase in the relative interaction of water with the protein. An increase in the number of interactions between water and the protein may initiate a protein's unfolding. This model for protein unfolding is supported by a range of recent experimental and computational data.

Source

Curr Opin Biotechnol. 1996 Aug;7(4):428-32.

Journal/Book/Conference Title

Current opinion in biotechnology

Related Resources

Link to Article in PubMed

PubMed ID

8768902

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