The role of protein-solvent interactions in protein unfolding
Department of Biochemistry and Molecular Pharmacology
Computer Simulation; Models, Molecular; Protein Denaturation; *Protein Folding; Proteins; Solvents; Urea; Water
Biochemistry, Biophysics, and Structural Biology | Pharmacology, Toxicology and Environmental Health
Protein unfolding occurs when the balance of forces between the protein's interaction with itself and the protein's interaction with its environment is disrupted. The disruption of this balance of forces may be as simple as a perturbance of the normal water structure around the protein. A decrease in the normal water-water interaction will result in an increase in the relative interaction of water with the protein. An increase in the number of interactions between water and the protein may initiate a protein's unfolding. This model for protein unfolding is supported by a range of recent experimental and computational data.
Curr Opin Biotechnol. 1996 Aug;7(4):428-32.
Current opinion in biotechnology
Schiffer, Celia A. and Dötsch, Volker, "The role of protein-solvent interactions in protein unfolding" (1996). Biochemistry and Molecular Pharmacology Publications and Presentations. 95.