Title

Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Publication Date

2004-11-25

Document Type

Article

Subjects

Drug Resistance, Viral; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Models, Molecular; Mutation; Oligopeptides; Protein Conformation

Disciplines

Biochemistry, Biophysics, and Structural Biology | Pharmacology, Toxicology and Environmental Health

Abstract

We observed a previously uncharacterized mutation in the protease substrate cleft, L23I, in 31 of 4,303 persons undergoing human immunodeficiency virus type 1 genotypic resistance testing. In combination with V82I, L23I was associated with a sevenfold reduction in nelfinavir susceptibility and a decrease in replication capacity. In combination with other drug resistance mutations, L23I was associated with multidrug resistance and a compensatory increase in replication capacity.

DOI of Published Version

10.1128/AAC.48.12.4864-4868.2004

Source

Antimicrob Agents Chemother. 2004 Dec;48(12):4864-8. Link to article on publisher's site

Journal/Book/Conference Title

Antimicrobial agents and chemotherapy

Related Resources

Link to Article in PubMed

PubMed ID

15561868

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