Title
Escherichia coli mutator genes
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology
Publication Date
1999-03-09
Document Type
Article
Subjects
DNA Repair; Escherichia coli; Escherichia coli Infections; *Genes, Bacterial; Humans; *Mutagenesis
Disciplines
Biochemistry, Biophysics, and Structural Biology | Pharmacology, Toxicology and Environmental Health
Abstract
The isolation and characterization of Escherichia coli mutator genes have led to a better understanding of DNA replication fidelity mechanisms and to the discovery of important DNA repair pathways and their relationship to spontaneous mutagenesis. Mutator strains in a population of cells can be beneficial in that they allow rapid selection of variants during periods of stress, such as drug exposure.
Source
Trends Microbiol. 1999 Jan;7(1):29-36.
Journal/Book/Conference Title
Trends in microbiology
Related Resources
PubMed ID
10068995
Repository Citation
Horst J, Wu T, Marinus MG. (1999). Escherichia coli mutator genes. Biochemistry and Molecular Biotechnology Publications. Retrieved from https://escholarship.umassmed.edu/bmp_pp/47