Escherichia coli mutator genes
Department of Biochemistry and Molecular Pharmacology
DNA Repair; Escherichia coli; Escherichia coli Infections; *Genes, Bacterial; Humans; *Mutagenesis
Biochemistry, Biophysics, and Structural Biology | Pharmacology, Toxicology and Environmental Health
The isolation and characterization of Escherichia coli mutator genes have led to a better understanding of DNA replication fidelity mechanisms and to the discovery of important DNA repair pathways and their relationship to spontaneous mutagenesis. Mutator strains in a population of cells can be beneficial in that they allow rapid selection of variants during periods of stress, such as drug exposure.
Trends Microbiol. 1999 Jan;7(1):29-36.
Trends in microbiology
Horst, Jens-Peter; Wu, Te-hui; and Marinus, Martin G., "Escherichia coli mutator genes" (1999). Biochemistry and Molecular Pharmacology Publications and Presentations. 47.