Escherichia coli mutator genes
Department of Biochemistry and Molecular Pharmacology
DNA Repair; Escherichia coli; Escherichia coli Infections; *Genes, Bacterial; Humans; *Mutagenesis
Biochemistry, Biophysics, and Structural Biology | Pharmacology, Toxicology and Environmental Health
The isolation and characterization of Escherichia coli mutator genes have led to a better understanding of DNA replication fidelity mechanisms and to the discovery of important DNA repair pathways and their relationship to spontaneous mutagenesis. Mutator strains in a population of cells can be beneficial in that they allow rapid selection of variants during periods of stress, such as drug exposure.
Trends Microbiol. 1999 Jan;7(1):29-36.
Trends in microbiology
Horst J, Wu T, Marinus MG. (1999). Escherichia coli mutator genes. Biochemistry and Molecular Pharmacology Publications. Retrieved from https://escholarship.umassmed.edu/bmp_pp/47