Title
The great GATC: DNA methylation in E. coli
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology
Publication Date
1989-05-01
Document Type
Article
Subjects
Base Sequence; Chromosomes, Bacterial; DNA Modification Methylases; DNA Replication; DNA, Bacterial; Escherichia coli; Gene Expression Regulation; Methylation
Disciplines
Biochemistry, Biophysics, and Structural Biology | Pharmacology, Toxicology and Environmental Health
Abstract
In Escherichia coli the methylation of the adenine in the sequence 5'-GATC-3' is catalysed by the dam gene product, a DNA adenine methylase. We review the proposed roles for this methylation, and the sequence it modifies, in mismatch repair, DNA-protein interaction, gene expression, the initiation of chromosome replication, chromosome segregation, chromosome structure and the occurrence of mutational hotspots.
Source
Trends Genet. 1989 May;5(5):139-43.
Journal/Book/Conference Title
Trends in genetics : TIG
Related Resources
PubMed ID
2667217
Repository Citation
Barras, Frederic and Marinus, Martin G., "The great GATC: DNA methylation in E. coli" (1989). Biochemistry and Molecular Pharmacology Publications and Presentations. 33.
https://escholarship.umassmed.edu/bmp_pp/33