Title

The great GATC: DNA methylation in E. coli

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Publication Date

1989-05-01

Document Type

Article

Subjects

Base Sequence; Chromosomes, Bacterial; DNA Modification Methylases; DNA Replication; DNA, Bacterial; Escherichia coli; Gene Expression Regulation; Methylation

Disciplines

Biochemistry, Biophysics, and Structural Biology | Pharmacology, Toxicology and Environmental Health

Abstract

In Escherichia coli the methylation of the adenine in the sequence 5'-GATC-3' is catalysed by the dam gene product, a DNA adenine methylase. We review the proposed roles for this methylation, and the sequence it modifies, in mismatch repair, DNA-protein interaction, gene expression, the initiation of chromosome replication, chromosome segregation, chromosome structure and the occurrence of mutational hotspots.

Source

Trends Genet. 1989 May;5(5):139-43.

Journal/Book/Conference Title

Trends in genetics : TIG

Related Resources

Link to Article in PubMed

PubMed ID

2667217

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