Title
Studies on mutagenesis and repair induced by platinum analogs
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology
Publication Date
1986-01-01
Document Type
Article
Subjects
Antineoplastic Agents; Carboplatin; DNA Repair; Escherichia coli; Genes, Bacterial; Mutagenicity Tests; *Mutagens; *Mutation; Organoplatinum Compounds; Structure-Activity Relationship
Disciplines
Biochemistry, Biophysics, and Structural Biology
Abstract
Mutagenesis and cytotoxicity were studied in Escherichia coli by iproplatin and carboplatin, two analogs of cisplatin (CDDP) currently undergoing clinical trial. As with CDDP, mutagenesis by these agents was mediated by the umuDC gene product. In contrast to CDDP, however, mismatch repair did not substantially contribute to survival of cells after exposure to these agents since dam-3 E. coli were not more sensitive than wild type E. coli. UvrA- E. coli, however were more sensitive to these analogs demonstrating that as with CDDP, uvr endonuclease-mediated excision contributes to the repair of DNA damage induced by platinum compounds.
DOI of Published Version
10.1016/0165-7992(86)90004-7
Source
Mutat Res. 1986 Jan;173(1):13-8.
Journal/Book/Conference Title
Mutation research
Related Resources
PubMed ID
3510378
Repository Citation
Fram RJ, Cusick PS, Marinus MG. (1986). Studies on mutagenesis and repair induced by platinum analogs. Biochemistry and Molecular Pharmacology Publications. https://doi.org/10.1016/0165-7992(86)90004-7. Retrieved from https://escholarship.umassmed.edu/bmp_pp/25