Title

Optogenetic Control of Voltage-Gated Calcium Channels

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Publication Date

3-23-2018

Document Type

Article

Disciplines

Biochemistry | Cellular and Molecular Physiology | Chemistry | Molecular Biology

Abstract

Voltage-gated Ca(2+) (CaV ) channels mediate Ca(2+) entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo-tunable modulation of CaV channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV -mediated physiological processes.

DOI of Published Version

10.1002/anie.201713080

Source

Angew Chem Int Ed Engl. 2018 Mar 23. doi: 10.1002/anie.201713080. Link to article on publisher's site

Journal/Book/Conference Title

Angewandte Chemie (International ed. in English)

Related Resources

Link to Article in PubMed

PubMed ID

29569306

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