Optogenetic Control of Voltage-Gated Calcium Channels
Department of Biochemistry and Molecular Pharmacology
Biochemistry | Cellular and Molecular Physiology | Chemistry | Molecular Biology
Voltage-gated Ca(2+) (CaV ) channels mediate Ca(2+) entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo-tunable modulation of CaV channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV -mediated physiological processes.
DOI of Published Version
Angew Chem Int Ed Engl. 2018 Mar 23. doi: 10.1002/anie.201713080. Link to article on publisher's site
Angewandte Chemie (International ed. in English)
Ma, Guolin; Liu, Jindou; Ke, Yuepeng; Liu, Xin; Li, Minyong; Wang, Fen; Han, Gang; Huang, Yun; Wang, Youjun; and Zhou, Yubin, "Optogenetic Control of Voltage-Gated Calcium Channels" (2018). Biochemistry and Molecular Pharmacology Publications and Presentations. 217.