Correlation of DNA adenine methylase activity with spontaneous mutability in Escherichia coli K-12
Department of Biochemistry and Molecular Pharmacology
Bacterial Proteins; DNA Repair; DNA, Bacterial; Escherichia coli; Methyltransferases; *Mutation; Plasmids; Site-Specific DNA-Methyltransferase (Adenine-Specific)
Biochemistry, Biophysics, and Structural Biology
Using a multicopy plasmid in which the tac promoter has been placed in front of the dam gene of Escherichia coli K-12, we show that levels of DNA adenine methylase activity are correlated with the spontaneous mutation frequency.
Gene. 1984 Apr;28(1):123-5.
Marinus MG, Poteete AR, Arraj JA. (1984). Correlation of DNA adenine methylase activity with spontaneous mutability in Escherichia coli K-12. Biochemistry and Molecular Pharmacology Publications. Retrieved from https://escholarship.umassmed.edu/bmp_pp/20