Correlation of DNA adenine methylase activity with spontaneous mutability in Escherichia coli K-12
Department of Biochemistry and Molecular Pharmacology
Bacterial Proteins; DNA Repair; DNA, Bacterial; Escherichia coli; Methyltransferases; *Mutation; Plasmids; Site-Specific DNA-Methyltransferase (Adenine-Specific)
Biochemistry, Biophysics, and Structural Biology
Using a multicopy plasmid in which the tac promoter has been placed in front of the dam gene of Escherichia coli K-12, we show that levels of DNA adenine methylase activity are correlated with the spontaneous mutation frequency.
Gene. 1984 Apr;28(1):123-5.
Marinus, Martin G.; Poteete, Anthony R.; and Arraj, Judy A., "Correlation of DNA adenine methylase activity with spontaneous mutability in Escherichia coli K-12" (1984). Biochemistry and Molecular Pharmacology Publications and Presentations. 20.