RNA processing and export

Sami Hocine, Albert Einstein College of Medicine
Robert H. Singer, Albert Einstein College of Medicine
David Grunwald, University of Massachusetts Medical School

At the time of publication, David Grünwald was not yet affiliated with the University of Massachusetts Medical School.

Abstract

Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.