Title

RNA processing and export

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; RNA Therapeutics Institute

Publication Date

2010-12

Document Type

Article

Subjects

Active Transport, Cell Nucleus; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic

Disciplines

Biochemistry | Biochemistry, Biophysics, and Structural Biology | Cell Biology | Molecular Biology

Abstract

Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.

DOI of Published Version

10.1101/cshperspect.a000752

Source

Hocine S, Singer RH, Grünwald D. RNA processing and export. Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a000752. doi:10.1101/cshperspect.a000752.

Journal/Book/Conference Title

Cold Spring Harbor perspectives in biology

Comments

At the time of publication, David Grünwald was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

20961978

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