RNA processing and export
Department of Biochemistry and Molecular Pharmacology; RNA Therapeutics Institute
Active Transport, Cell Nucleus; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic
Biochemistry | Biochemistry, Biophysics, and Structural Biology | Cell Biology | Molecular Biology
Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.
DOI of Published Version
Hocine S, Singer RH, Grünwald D. RNA processing and export. Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a000752. doi:10.1101/cshperspect.a000752.
Cold Spring Harbor perspectives in biology
Hocine, Sami; Singer, Robert H.; and Grunwald, David, "RNA processing and export" (2010). Biochemistry and Molecular Pharmacology Publications and Presentations. 169.