Nuclear export dynamics of RNA-protein complexes
Department of Biochemistry and Molecular Pharmacology; RNA Therapeutics Institute
Active Transport, Cell Nucleus; Cell Nucleus; Cytoplasm; Humans; Microscopy; Nuclear Pore; RNA; Ribonucleoproteins; Ribosomes
Biochemistry | Biochemistry, Biophysics, and Structural Biology | Biophysics | Cell Biology | Molecular Biology | Structural Biology
The central dogma of molecular biology - DNA makes RNA makes proteins - is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclear-pore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work.
DOI of Published Version
Grünwald D, Singer RH, Rout M. Nuclear export dynamics of RNA-protein complexes. Nature. 2011 Jul 20;475(7356):333-41. doi: 10.1038/nature10318. Link to article on publisher's site
Grunwald, David; Singer, Robert H.; and Rout, Michael, "Nuclear export dynamics of RNA-protein complexes" (2011). Biochemistry and Molecular Pharmacology Publications and Presentations. 165.