Nuclear export dynamics of RNA-protein complexes

David Grunwald, University of Massachusetts Medical School
Robert H. Singer, Albert Einstein College of Medicine
Michael Rout, Rockefeller University

At the time of publication, David Grünwald was not yet affiliated with the University of Massachusetts Medical School.


The central dogma of molecular biology - DNA makes RNA makes proteins - is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclear-pore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work.