Title

Nuclear export dynamics of RNA-protein complexes

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; RNA Therapeutics Institute

Publication Date

2011-07-20

Document Type

Article

Subjects

Active Transport, Cell Nucleus; Cell Nucleus; Cytoplasm; Humans; Microscopy; Nuclear Pore; RNA; Ribonucleoproteins; Ribosomes

Disciplines

Biochemistry | Biochemistry, Biophysics, and Structural Biology | Biophysics | Cell Biology | Molecular Biology | Structural Biology

Abstract

The central dogma of molecular biology - DNA makes RNA makes proteins - is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclear-pore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work.

DOI of Published Version

10.1038/nature10318

Source

Grünwald D, Singer RH, Rout M. Nuclear export dynamics of RNA-protein complexes. Nature. 2011 Jul 20;475(7356):333-41. doi: 10.1038/nature10318. Link to article on publisher's site

Journal/Book/Conference Title

Nature

Comments

At the time of publication, David Grünwald was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

21776079

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