Title

Multiscale dynamics in nucleocytoplasmic transport

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; RNA Therapeutics Institute

Publication Date

2012-2

Document Type

Article

Subjects

*Active Transport, Cell Nucleus; Animals; Biological Transport; Cell Nucleus; Cytoplasm; Eukaryotic Cells; Models, Biological; Nuclear Pore; Nuclear Pore Complex Proteins

Disciplines

Biochemistry | Biochemistry, Biophysics, and Structural Biology | Biophysics | Cell Biology | Molecular Biology | Structural Biology

Abstract

The nuclear pore complex (NPC) has long been viewed as a point-like entry and exit channel between the nucleus and the cytoplasm. New data support a different view whereby the complex displays distinct spatial dynamics of variable duration ranging from milliseconds to events spanning the entire cell cycle. Discrete interaction sites outside the central channel become apparent, and transport regulation at these sites seems to be of greater importance than currently thought. Nuclear pore components are highly active outside the NPC or impact the fate of cargo transport away from the nuclear pore. The NPC is a highly dynamic, crowded environment-constantly loaded with cargo while providing selectivity based on unfolded proteins. Taken together, this comprises a new paradigm in how we view import/export dynamics and emphasizes the multiscale nature of NPC-mediated cellular transport.

DOI of Published Version

10.1016/j.ceb.2011.11.011

Source

Grünwald D, Singer RH. Multiscale dynamics in nucleocytoplasmic transport. Curr Opin Cell Biol. 2012 Feb;24(1):100-6. doi: 10.1016/j.ceb.2011.11.011. Link to article on publisher's site

Journal/Book/Conference Title

Current opinion in cell biology

Comments

At the time of publication, David Grünwald was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

22196930

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