Human monoclonal antibody MBL-HCV1 delays HCV viral rebound following liver transplantation: a randomized controlled study
Authors
Chung, R. T.Gordon, F. D.
Curry, M. P.
Schiano, T. D.
Emre, S.
Corey, K.
Markmann, J. F.
Hertl, M.
Pomposelli, J. J.
Pomfret, E. A.
Florman, S.
Schilsky, M.
Broering, Teresa J.
Finberg, Robert W.
Szabo, Gyongyi
Zamore, Phillip D.
Khettry, U.
Babcock, Gregory J.
Ambrosino, Donna M.
Leav, Brett A.
Leney, Mark
Smith, H. L.
Molrine, Deborah C.
UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyDepartment of Medicine
MassBiologics
Document Type
Journal ArticlePublication Date
2013-04-01Keywords
Liver TransplantationHepacivirus
Hepatitis C Antibodies
Biochemistry, Biophysics, and Structural Biology
Hepatology
Immunology and Infectious Disease
Therapeutics
Virus Diseases
Metadata
Show full item recordAbstract
Rapid allograft infection complicates liver transplantation (LT) in patients with hepatitis C virus (HCV). Pegylated interferon-alpha and ribavirin therapy after LT has significant toxicity and limited efficacy. The effect of a human monoclonal antibody targeting the HCV E2 glycoprotein (MBL-HCV1) on viral clearance was examined in a randomized, double-blind, placebo-controlled pilot study in patients infected with HCV genotype 1a undergoing LT. Subjects received 11 infusions of 50 mg/kg MBL-HCV1 (n=6) or placebo (n=5) intravenously with three infusions on day of transplant, a single infusion on days 1 through 7 and one infusion on day 14 after LT. MBL-HCV1 was well-tolerated and reduced viral load for a period ranging from 7 to 28 days. Median change in viral load (log10 IU/mL) from baseline was significantly greater (p=0.02) for the antibody-treated group (range -3.07 to -3.34) compared to placebo group (range -0.331 to -1.01) on days 3 through 6 posttransplant. MBL-HCV1 treatment significantly delayed median time to viral rebound compared to placebo treatment (18.7 days vs. 2.4 days, pSource
Am J Transplant. 2013 Apr;13(4):1047-54. doi: 10.1111/ajt.12083. Link to article on publisher's site
DOI
10.1111/ajt.12083Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26028PubMed ID
23356386Related Resources
ae974a485f413a2113503eed53cd6c53
10.1111/ajt.12083