Small RNA-Directed Silencing: The Fly Finds Its Inner Fission Yeast
Department of Biochemistry and Molecular Pharmacology
RNA, Small Interfering
Biochemistry, Biophysics, and Structural Biology | Genetics and Genomics | Molecular Genetics
Several recent studies demonstrate that piRNAs guide Piwi protein to repress transposon transcription in fly ovaries, much as fission yeast use siRNAs to silence repeat sequences. Still mysterious though is how Piwi targets euchromatic transposons for silencing, but not the specialized heterochromatic loci that produce piRNA precursors.
DOI of Published Version
Curr Biol. 2013 Apr 22;23(8):R318-20. doi: 10.1016/j.cub.2013.03.033. Link to article on publisher's site
Current biology : CB
Ge, Daniel Tianfang and Zamore, Phillip D., "Small RNA-Directed Silencing: The Fly Finds Its Inner Fission Yeast" (2013). Biochemistry and Molecular Pharmacology Publications and Presentations. 156.