The challenge of developing robust drugs to overcome resistance
Department of Biochemistry and Molecular Pharmacology; Institute for Drug Resistance
Drug Design; Drug Resistance, Viral; HIV Protease Inhibitors; HIV-1; Molecular Targeted Therapy
Biochemistry, Biophysics, and Structural Biology | Microbiology
Drug resistance is problematic in microbial disease, viral disease and cancer. Understanding at the outset that resistance will impact the effectiveness of any new drug that is developed for these disease categories is imperative. In this Feature, we detail approaches that have been taken with selected drug targets to reduce the susceptibility of new drugs to resistance mechanisms. We will also define the concepts of robust drugs and resilient targets, and discuss how the design of robust drugs and the selection of resilient targets can lead to successful strategies for combating resistance.
DOI of Published Version
Drug Discov Today. 2011 Sep;16(17-18):755-61. Epub 2011 Jul 19. Link to article on publisher's site
Drug discovery today
Anderson, Amy C.; Pollastri, Michael P.; Schiffer, Celia A.; and Peet, Norton P., "The challenge of developing robust drugs to overcome resistance" (2011). Biochemistry and Molecular Pharmacology Publications and Presentations. 132.