Title

The challenge of developing robust drugs to overcome resistance

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; Institute for Drug Resistance

Publication Date

2011-09-26

Document Type

Article

Subjects

Drug Design; Drug Resistance, Viral; HIV Protease Inhibitors; HIV-1; Molecular Targeted Therapy

Disciplines

Biochemistry, Biophysics, and Structural Biology | Microbiology

Abstract

Drug resistance is problematic in microbial disease, viral disease and cancer. Understanding at the outset that resistance will impact the effectiveness of any new drug that is developed for these disease categories is imperative. In this Feature, we detail approaches that have been taken with selected drug targets to reduce the susceptibility of new drugs to resistance mechanisms. We will also define the concepts of robust drugs and resilient targets, and discuss how the design of robust drugs and the selection of resilient targets can lead to successful strategies for combating resistance.

DOI of Published Version

10.1016/j.drudis.2011.07.001

Source

Drug Discov Today. 2011 Sep;16(17-18):755-61. Epub 2011 Jul 19. Link to article on publisher's site

Journal/Book/Conference Title

Drug discovery today

Related Resources

Link to Article in PubMed

PubMed ID

21784168

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