The challenge of developing robust drugs to overcome resistance

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; Institute for Drug Resistance



Document Type


Medical Subject Headings

Drug Design; Drug Resistance, Viral; HIV Protease Inhibitors; HIV-1; Molecular Targeted Therapy


Drug resistance is problematic in microbial disease, viral disease and cancer. Understanding at the outset that resistance will impact the effectiveness of any new drug that is developed for these disease categories is imperative. In this Feature, we detail approaches that have been taken with selected drug targets to reduce the susceptibility of new drugs to resistance mechanisms. We will also define the concepts of robust drugs and resilient targets, and discuss how the design of robust drugs and the selection of resilient targets can lead to successful strategies for combating resistance.

Rights and Permissions

Citation: Drug Discov Today. 2011 Sep;16(17-18):755-61. Epub 2011 Jul 19. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID